{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:45:52Z","timestamp":1789663552905,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with Type 1 von Willebrand disease (VWD) have reduced amounts of von Willebrand factor (VWF) in their blood. Desmopressin (DDAVP) has been used to raise the blood levels of VWF in these patients. However, not all patients with Type 1 VWD are known to respond to DDAVP therapy. We sought to compare the levels of Factor VIII, VWF antigen (VWF:Ag), VWF ristocetin cofactor (VWF:RCo), and fibrinogen at different time points after administration of DDAVP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted at a single institution on 89 patients with Type 1 VWD who received a single intravenous dose of 0.3\u00a0\u03bcg\/kg DDAVP. Levels of Factor VIII, VWF:Ag, VWF:RCo, and fibrinogen were measured before and then 30, 60, 90, and 120\u00a0minutes after completion of DDAVP administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median levels of Factor VIII, VWF:Ag, and VWF:RCo were significantly elevated (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) at 30 (175\u00a0IU\/dL, 111\u00a0IU\/dL, 127\u00a0IU\/dL), 60 (218\u00a0IU\/dL, 138\u00a0IU\/dL, 139\u00a0IU\/dL), and 90 (212\u00a0IU\/dL, 134\u00a0IU\/dL, 130\u00a0IU\/dL) minutes time points when compared to their respective baseline values (71\u00a0IU\/dL, 54\u00a0IU\/dL, 54\u00a0IU\/dL). At 60\u00a0minutes, 96% of subjects were responders, but three subjects failed to respond at any time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Measurement of levels of Factor VIII, VWF:Ag, and VWF:RCo, optimally at 60\u00a0minutes after the DDAVP infusion, is sufficient to confirm a patient as a responder in a DDAVP challenge test. Curtailing the number of time points of measurement will result in significant savings in cost and time to patients and their providers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12978","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T16:06:36Z","timestamp":1549641996000},"page":"325-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quantitative analysis of desmopressin (DDAVP) response in adult patients with type 1 von Willebrand disease"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9390-0424","authenticated-orcid":false,"given":"Achuta K.","family":"Guddati","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Georgia Cancer Center Augusta University Augusta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel P.","family":"Rosovsky","sequence":"additional","affiliation":[{"name":"Division of Hematology, Harvard Medical School Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Van Cott","sequence":"additional","affiliation":[{"name":"Department of Pathology, Harvard Medical School Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Kuter","sequence":"additional","affiliation":[{"name":"Division of Hematology, Harvard Medical School Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.6.1691.1691"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01848.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-498303"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92790-4"},{"issue":"4","key":"e_1_2_7_6_1","first-page":"662","article-title":"Studies on the prolonged bleeding time in von Willebrand's disease","volume":"88","author":"Mannucci PM","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200311000-00010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02146.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02789.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.6.1997.1997"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2072"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.3237"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"39","article-title":"Von Willebrand factor in Italian centenarians","volume":"88","author":"Coppola R","year":"2003","journal-title":"Haematologica"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.12978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12978","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijlh.12978","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.12978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T08:10:13Z","timestamp":1694247013000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.12978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,8]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/ijlh.12978"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.12978","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,8]]},"assertion":[{"value":"2018-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}