{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:16:32Z","timestamp":1747185392386,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Myelodysplastic\/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS\/MPN\u2010RS\u2010T) is a rare disease in the 2016 revised World Health Organization (WHO) classification. Diagnostic criteria include the following: persistent thrombocytosis (&gt;450\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L) with clustering of atypical megakaryocytes, refractory anemia, dyserythropoiesis with ring sideroblasts, and the presence of the spliceosome factor 3b subunit (<jats:italic>SF3B1<\/jats:italic>) mutation. It is unclear if anemia should be a required criterion for this diagnosis as cases which show all other features of MDS\/MPN\u2010RS\u2010T but without anemia exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched for borderline cases of MDS\/MPN\u2010RS\u2010T in which refractory anemia was absent at diagnosis in two major academic institutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three cases without anemia were identified. These cases all showed other classic morphologic and clinical features of MDS\/MPN\u2010RS\u2010T, including thrombocytosis, atypical megakaryocytes with clustering, and characteristic <jats:italic>SF3B1<\/jats:italic> and <jats:italic>JAK2<\/jats:italic> V617F mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given these findings, the requirement of refractory anemia as a diagnostic criterion for MDS\/MPN\u2010RS\u2010T should be re\u2010evaluated. Removal of refractory anemia as a diagnostic criterion would incorporate current borderline cases and extend the spectrum of this disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12981","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T16:07:06Z","timestamp":1551283626000},"page":"345-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Revisiting diagnostic criteria for myelodysplastic\/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis: Borderline cases without anemia exist"],"prefix":"10.1111","volume":"41","author":[{"given":"Peng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahid","family":"Shahmarvand","sequence":"additional","affiliation":[{"name":"Department of 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