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However, their roles in severe aplastic anemia (SAA) have not been elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we investigated the quantities, phenotypes, cytokine secretion abilities, and the cytotoxicities of peripheral CD56<jats:sup>bright<\/jats:sup> NK cells along with CD56<jats:sup>dim<\/jats:sup> NK cells obtained from patients with SAA, SAA in remission (R\u2010SAA), and healthy controls (HC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed the decreased quantities of CD56<jats:sup>bright<\/jats:sup> NK cells in SAA compared with in R\u2010SAA and HC. In SAA, the quantities of CD56<jats:sup>bright<\/jats:sup> NK cells correlated with the disease severity. Activating receptors NKp46 and NKp44 on CD56<jats:sup>bright<\/jats:sup> NK cells were upregulated while inhibiting receptor NKG2A was downregulated in SAA. CD56<jats:sup>bright<\/jats:sup> NK cells obtained from SAA patients produced increased IL\u201010 and decreased IFN\u2010\u03b3 in vitro compared with cells obtained from HC, while TNF\u2010\u03b1 and IL\u201013 productions were not different between two groups. Under a 7\u2010day prestimulation with IL\u20102 and IL\u201012, the serum concentrations of which were higher in SAA patients, CD56<jats:sup>bright<\/jats:sup> NK obtained from HC also produced increased IL\u201010 mRNAs. There were no differences of cytotoxicites between CD56<jats:sup>bright<\/jats:sup> NK cells in SAA and in HC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We discovered that CD56<jats:sup>bright<\/jats:sup> NK cells exhibited abnormal receptor expressions and cytokine production in SAA, and they were related with the severity of illness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12982","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T10:50:11Z","timestamp":1550573411000},"page":"353-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["CD56<sup>bright<\/sup> natural killer cells exhibit abnormal phenotype and function in severe aplastic 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