{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T13:46:15Z","timestamp":1783172775175,"version":"3.54.6"},"reference-count":38,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000152","name":"Canadian Hemophilia Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 97942"],"award-info":[{"award-number":["MOP 97942"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Platelet function disorders (<jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content>) are an important group of bleeding disorders that require validated and practical laboratory strategies for diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This review summarizes the authors\u2019 experiences, current literature, and an international survey to evaluate the practices of diagnostic laboratories that offer tests for <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blood counts, blood film review, and aggregation tests are the most commonly performed investigations for <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content> and help determine whether there is thrombocytopenia and\/or defective platelet function due to a variety of causes. The performance characteristics of tests for <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content>, and the level of evidence that these tests detect bleeding problems, are important issues to determine where tests are useful for diagnostic or correlative purposes, or research only uses. Platelet aggregation assays, and quantitative analysis of platelet dense granule numbers, are tests with good performance characteristics that detect abnormalities associated with increased bleeding in a significant proportion of individuals referred for <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content> investigations. Lumiaggregometry estimates of platelet adenosine triphosphate release show greater variability which limits the diagnostic usefulness. Diagnostic laboratories report that fiscal and other constraints, including a lack of high\u2010quality evidence, limit their ability to offer an expanded test menu for <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content> are clinically important bleeding disorders that remain challenging for diagnostic laboratories to investigate. While some <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content> tests are well validated for diagnostic purposes, gaps in scientific evidence and resource limitations influence diagnostic laboratory decisions on which <jats:styled-content style=\"fixed-case\">PFD<\/jats:styled-content> tests to offer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.12995","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T05:29:15Z","timestamp":1557379755000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Update on diagnostic testing for platelet function disorders: What is practical and useful?"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2843-0817","authenticated-orcid":false,"given":"Catherine P. M.","family":"Hayward","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton Ontario Canada"},{"name":"Department of Medicine McMaster University Hamilton Ontario Canada"},{"name":"Hamilton Regional Laboratory Medicine Program Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6431-5525","authenticated-orcid":false,"given":"Karen A.","family":"Moffat","sequence":"additional","affiliation":[{"name":"Department of Medicine McMaster University Hamilton Ontario Canada"},{"name":"Hamilton Regional Laboratory Medicine Program Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Brunet","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Carlino","sequence":"additional","affiliation":[{"name":"Hamilton Regional Laboratory Medicine Program Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Plumhoff","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Meijer","sequence":"additional","affiliation":[{"name":"ECAT Foundation Voorschoten The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Zehnder","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Medicine Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13169"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12332"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.160754"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03975.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12801"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12822"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12792"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12077"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-4077"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08793.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-16-02-0002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12231"},{"key":"e_1_2_7_14_1","unstructured":"ChristieDJ AvariT CarringtonLR et\u00a0al.Clinical and Laboratory Standards Institute (CLSI). 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