{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:53:12Z","timestamp":1787014392737,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hereditary hemolytic anemia (\n                    <jats:styled-content style=\"fixed-case\">HHA<\/jats:styled-content>\n                    ) is a group of genetically and phenotypically heterogeneous disorders characterized by premature destruction of red blood cells (\n                    <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\n                    s) with clinical manifestations ranging from asymptomatic to marked hemolytic anemia. There are three main categories of\n                    <jats:styled-content style=\"fixed-case\">HHA<\/jats:styled-content>\n                    : (a)\n                    <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\n                    membrane defects; (b) hemoglobinopathies\/thalassemias; and (c)\n                    <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\n                    enzyme deficiencies. Hyperbilirubinemia is a frequent consequence of hemolytic anemia and can lead to bilirubin\u2010associated neurotoxicity in neonates and to jaundice, and formation of gall stones in adults. Hyperbilirubinemia can also be caused by impaired bilirubin conjugation due to polymorphisms and mutations in genes involved in bilirubin metabolism (eg,\n                    <jats:italic>UGT1A1<\/jats:italic>\n                    ). Neonates with\n                    <jats:styled-content style=\"fixed-case\">HHA<\/jats:styled-content>\n                    and co\u2010inherited variants impairing bilirubin conjugation are at increased risk of bilirubin\u2010associated toxicity. Prior to the advent of next\u2010generation sequencing (\n                    <jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content>\n                    ), molecular diagnosis of these disorders was limited to targeted single gene Sanger sequencing. However,\n                    <jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content>\n                    is making its way into the standard diagnostic workup of complex and multigene disorders like\n                    <jats:styled-content style=\"fixed-case\">HHA<\/jats:styled-content>\n                    . This review will focus on the molecular updates of\n                    <jats:styled-content style=\"fixed-case\">HHA<\/jats:styled-content>\n                    with particular focus on the neonatal and pediatric population.\n                  <\/jats:p>","DOI":"10.1111\/ijlh.13014","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T01:28:31Z","timestamp":1557365311000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Molecular diagnostic update in hereditary hemolytic anemia and neonatal hyperbilirubinemia"],"prefix":"10.1111","volume":"41","author":[{"given":"Anton","family":"Rets","sequence":"first","affiliation":[{"name":"Department of Pathology University of Utah Health Salt Lake City Utah"},{"name":"ARUP Laboratories Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam 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