{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T05:50:57Z","timestamp":1785563457951,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The Sysmex XN\u201010 automated hematology analyzer (Sysmex Corporation) is routinely used in hematology laboratories to perform complete blood cell count with differential (CBC w\/ diff). The sensitivity of this system for blast detection is unclear, since many prior studies evaluating the blast flagging capabilities of Sysmex XN series used the white precursor cell (WPC) channel, which is not cleared for use in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the blast flagging capabilities of the Sysmex XN\u201010 compared with CellaVision (a cell image analyzer)\u2010assisted visual hematology results. We evaluated the following flags: \u201cblasts?\/abnormal lymph?\u201d and \u201cimmature granulocytes present\u201d and compared differences in turnaround time between methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We collected data on 2239 CBC w\/ diff Sysmex automated analyzer differential and CellaVision\u2010assisted visual differential from the inpatient hematology\u2010oncology population of a tertiary care medical center. Solely analyzing the first CBC\/diff from each unique patient, both flags had a combined sensitivity of 100%, specificity of 50.2%, PPV of 21.7%, and NPV of 100%. The mean turnaround time for the automated differential was 19.5\u00a0minutes (SD\u00a035.9\u00a0minutes) compared with 66.4\u00a0minutes for the CellaVision\u2010assisted visual differential (SD\u00a068.5\u00a0minutes; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; Figure 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Sysmex XN\u201010 abnormal lymphocyte\/blast and immature granulocytes flags had excellent sensitivity and acceptable specificity in detecting circulating blasts with shorter turnaround time than the CellaVision\u2010assisted visual differential. Our study suggests that automated differentials performed on Sysmex XN\u201010 can replace visual differentials as a first\u2010line screening method for blast detection with improved turnaround time in hematology\u2010oncology populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13069","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T17:10:10Z","timestamp":1559668210000},"page":"601-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Blast flagging of the Sysmex XN\u201010 hematology analyzer with supervised cell image analysis: Impact on quality parameters"],"prefix":"10.1111","volume":"41","author":[{"given":"Jessica","family":"Petrone","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0697-9454","authenticated-orcid":false,"suffix":"Jr","given":"Ronald","family":"Jackups","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Eby","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Shimer","sequence":"additional","affiliation":[{"name":"Clinical Hematology Laboratory Barnes\u2010Jewish Hospital St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Anderson","sequence":"additional","affiliation":[{"name":"Clinical Hematology Laboratory Barnes\u2010Jewish Hospital St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4614-681X","authenticated-orcid":false,"given":"John L.","family":"Frater","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"11","volume-title":"Williams Hematology","author":"Ryan DH","year":"2016"},{"key":"e_1_2_7_3_1","first-page":"510","volume-title":"Henry's Clinical Diagnosis and Management by Laboratory Methods","author":"Vajpayee N","year":"2017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPDLR4KGKAFW4W"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPE5R4SOQBUULZ"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP4V4EXYFFOELL"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12254"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12717"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202640"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.01.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.08.020"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.01.014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP7D8ECZRXGWCG"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12575"},{"key":"e_1_2_7_15_1","unstructured":"Clinical and Laboratory Standards Institute (CLSI).Reference leukocyte (WBC) differential count (proportional) and evaluation of instrumental methods; approved standards. 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