{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T20:35:39Z","timestamp":1775680539404,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>A prototype of good prognosis, t(8;21)\u2010positive AML, has diverse clinical and genetic features which affect its outcome. This study aimed at evaluating the clinico\u2010pathological spectrum of t(8;21)\u2010positive AML and ascertaining prognostic factors influencing its outcome in the Indian subcontinent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 75 cases of t(8;21)\u2010positive AML diagnosed over a period of six years (2013\u20102018) was carried out. Detailed clinical and laboratory data of the patients were collected from the electronic medical records and reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 19.5\u00a0years (range 5\u201075\u00a0years) with a M:F of 1.7. Myeloid sarcoma was observed in 9.3% cases. There were 85% FAB AML\u2010M2, 8% AML\u2010M1, and 7% AML\u2010M4 subtypes. Prominent morphological characteristics included dyspoiesis in maturing myeloid cells (83%), long thin tapered Auer rods (58%), cytoplasmic vacuoles (58%), eosinophilia (50%), and mast cells (22%). Auer rods in maturing granulocytes (4% cases) were highly suggestive of the translocation. Additional cytogenetic abnormalities were present in 53% cases. Seventy\u2010one percent (25\/35) achieved CR. The overall survival (OS) was 40%, with a median follow\u2010up of 27\u00a0months (range 4\u201057\u00a0months). None of the hematological or cytogenetic factors correlated with OS, except for the presence of myeloid sarcoma which had a trend toward poor survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Outcome of t(8;21) AML is not influenced by any of the clinico\u2010pathological parameters, except for a myeloid sarcoma, which may herald a poor prognosis. Recognition of this distinct subtype of AML would facilitate further molecular screening for risk stratification in resource\u2010constrained settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13121","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T17:30:42Z","timestamp":1573752642000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Morphological characteristics, cytogenetic profile, and outcome of <i>RUNX1\u2010RUNX1T1<\/i>\u2010positive acute myeloid leukemia: Experience of an Indian tertiary care center"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-9188","authenticated-orcid":false,"given":"Ruchi","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Uttar Pradesh Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Uttar Pradesh Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yatendra","family":"Parashar","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Uttar Pradesh Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-2092","authenticated-orcid":false,"given":"Khaliqur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Uttar Pradesh Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-2656","authenticated-orcid":false,"given":"Manish Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Uttar Pradesh Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Uttar Pradesh Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshul","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Uttar Pradesh Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soniya","family":"Nityanand","sequence":"additional","affiliation":[{"name":"Department of Hematology Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS) Uttar Pradesh Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"issue":"2","key":"e_1_2_8_3_1","first-page":"109","article-title":"Identification of a translocation with quinacrine fluorescence in a patient with acute leukemia","volume":"16","author":"Rowley JD","year":"1973","journal-title":"Ann Genet"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-254441"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-852822"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301689"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06229.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3517"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009054882"},{"key":"e_1_2_8_11_1","first-page":"1037","article-title":"Prognostic Factor Analysis in Core\u2010Binding Factor\u2010positive Acute Myeloid Leukemia","volume":"34","author":"Jung HA","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12333"},{"issue":"3","key":"e_1_2_8_13_1","first-page":"256","article-title":"Haematological & molecular profile of acute myelogenous leukaemia in India","volume":"129","author":"Sazawal S","year":"2009","journal-title":"Indian J Med Res"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13406"},{"key":"e_1_2_8_15_1","first-page":"127","article-title":"Response to Induction Chemotherapy Predicts Survival in AML: A Single Centre Experience from North India","volume":"6","author":"Gupta A","year":"2018","journal-title":"Indian J Cancer Edu Res"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353118"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401592"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23220"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.8329"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.036"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.603447"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2322"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404905"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402871"},{"key":"e_1_2_8_25_1","unstructured":"LeeKW ChoiIS RohEY et al.Adult patients with t(8;21) acute myeloid leukemia had no superior treatment outcome to those without t(8;21): a single institution\u2019s experience."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.03.012"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.15.610"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06276.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.92"},{"issue":"9","key":"e_1_2_8_30_1","first-page":"9312","article-title":"Clinical characteristics of t(8;21) acute myeloid leukemia with AML1\/ETO fusion in a single center in China","volume":"11","author":"Dong P","year":"2018","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404491"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.415954.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428199609054825"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-780817"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-009-0023-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-015-1977-3"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2007.00913.x"},{"issue":"8","key":"e_1_2_8_38_1","first-page":"1288","article-title":"Fifty\u2010one patients with acute myeloid leukemia and translocation t(8;21)(q22;q22): an additional deletion in 9q is an adverse prognostic factor","volume":"10","author":"Schoch C","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12779"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.13121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.13121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijlh.13121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.13121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:38:39Z","timestamp":1694162319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.13121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,14]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/ijlh.13121"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.13121","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,14]]},"assertion":[{"value":"2019-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}