{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:46:35Z","timestamp":1772160395314,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"WADA\u2019s Science Department","award":["R19M02RF"],"award-info":[{"award-number":["R19M02RF"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The Athlete's Biological Passport (ABP) is a tool for the indirect detection of blood doping. Guidelines from the World Anti\u2010Doping Agency (WADA) require a 2\u00a0hours delay after any physical exercise, and to be seated for 10\u00a0minutes before collecting an ABP sample. This study investigated posture\u2010related hematological variations with changes in body position during blood sampling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten successive venous blood samples from 38 subjects were collected in three situations: immediately after 10\u2010minutes of normalized activity (B1), after 10\u2010minutes seated (B2, typical reference sample in an anti\u2010doping context), after a 50\u00a0m walk (B3), after 5 and 10\u2010minutes in a seated position again (B4 and B5), and finally after 5\u201030\u00a0minutes supine (B6\u2010B10). Hemoglobin concentration [Hb] and hematocrit (Hct) were determined by flow cytometry to assess putative posture\u2010related variations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Reticulocytes percentage was unchanged in all conditions, [Hb] and Hct were stable after at least 10\u2010minutes in a seated position. Due to shifts in plasma volume, [Hb] and Hct increased slightly but significantly higher after changing posture for a short walk (+0.1\u00a0gr\/dL [\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.008] and +0.4% [\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01] respectively), but readjusted to previous levels after only 5\u00a0minutes. Supine position (&gt;10\u00a0minutes) induced decreases of [Hb] (\u22120.2\u00a0g\/dL in average,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) and Hct (\u22121.1%, in average,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The observed variations in [Hb] and Hct may have minor clinical significance, while they underline the need to follow strict guidelines for posture before and during blood sampling in an anti\u2010doping context.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.13140","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T10:29:28Z","timestamp":1575973768000},"page":"61-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Does body position before and during blood sampling influence the Athlete Biological Passport variables?"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3816-1259","authenticated-orcid":false,"given":"Tiffany","family":"Astolfi","sequence":"first","affiliation":[{"name":"REDs, Research and Expertise in antiDoping sciences University of Lausanne Lausanne Switzerland"},{"name":"ISSUL, Institute of Sport Sciences, University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yorck Olaf","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Aspetar Orthopaedic and Sports Medicine Hospital Doha Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Crettaz von Roten","sequence":"additional","affiliation":[{"name":"ISSUL, Institute of Sport Sciences, University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martial","family":"Saugy","sequence":"additional","affiliation":[{"name":"REDs, Research and Expertise in antiDoping sciences University of Lausanne Lausanne Switzerland"},{"name":"ISSUL, Institute of Sport Sciences, University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6029-9516","authenticated-orcid":false,"given":"Raphael","family":"Faiss","sequence":"additional","affiliation":[{"name":"REDs, Research and Expertise in antiDoping sciences University of Lausanne Lausanne Switzerland"},{"name":"ISSUL, Institute of Sport Sciences, University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"AikinR.The ABP in 2018 \u2013 status report. 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