{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T02:40:06Z","timestamp":1773801606254,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Thromboelastography (TEG) is a whole blood clotting assay largely used in major surgeries and trauma to monitor patients' in vivo hemostatic status. Standardization of kaolin\u2010activated citrated whole blood thromboelastography is not done in the Indian population. This study primarily aims to derive reference ranges of kaolin\u2010activated TEG for healthy volunteers in the Indian population. Secondarily, it aims to study the age\u2010 and gender\u2010related hemostatic changes in the study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 120 healthy volunteers were enrolled (55 adult males, 32 adult females, and 33 children). The volunteers were interviewed for any bleeding history or drug intake which affects coagulation. Kaolin\u2010activated TEG was performed on citrated whole blood, and parameters including R\u2010time, K\u2010time, angle, MA, LY30, and CI were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Derived reference range for total volunteers irrespective of age and sex were as follows: R\u2010time: 3.8\u201010.6, K\u2010time: 1.2\u20103.1, angle: 44.9\u201072.0, MA: 41.2\u201064.5, LY30: 0\u20109.9, and CI: \u22123.7 to 3.4. Statistically significant difference was observed in different age and sex groups for R\u2010time, K\u2010time, and angle. About 40% of the volunteers had at least one abnormal parameter according to the manufacturer's reference range which decreased to 12.5% when the derived reference ranges were considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Gender\u2010 and age\u2010related variances were observed in reference ranges of our population and which was also differed from the other ethnic population. Many of our healthy volunteers were categorized as coagulopathic when manufacturer's reference range was considered. So, it is important to derive the reference range of the target population before using the TEG into clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13148","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T09:09:18Z","timestamp":1577783358000},"page":"180-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Age\u2010 and gender\u2010related reference ranges for thromboelastography from a healthy Indian population"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5461-5957","authenticated-orcid":false,"given":"Javed","family":"Ahammad","sequence":"first","affiliation":[{"name":"Melaka Manipal Medical College Manipal Academy of Higher Education Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamma","family":"Kurien","sequence":"additional","affiliation":[{"name":"Melaka Manipal Medical College Manipal Academy of Higher Education Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shamee","family":"Shastry","sequence":"additional","affiliation":[{"name":"Kasturba Medical College Manipal Academy of Higher Education Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitesh H.","family":"Shah","sequence":"additional","affiliation":[{"name":"Kasturba Medical College Manipal Academy of Higher Education Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Nayak","sequence":"additional","affiliation":[{"name":"Melaka Manipal Medical College Manipal Academy of Higher Education Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asha","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Statistics Manipal Academy of Higher Education Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulochana","family":"Badagabettu","sequence":"additional","affiliation":[{"name":"Manipal College of Nursing Manipal Academy of Higher Education Manipal India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199704000-00023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07101.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/69.3.307"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199902000-00016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199502000-00006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12458"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.130896"},{"key":"e_1_2_8_9_1","unstructured":"TEG\u00ae 5000 System\u2010 User Manual\u2010 P\/N 06\u2013510\u2010US Manual revision: AD December2011."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200110000-00008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2009001200015"},{"key":"e_1_2_8_12_1","unstructured":"Centers for Disease Control and Prevention.Considering the clinical laboratory improvement amendment.http:\/\/wwwn.cdc.gov\/clia\/regs\/toc.aspx. 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