{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:58:51Z","timestamp":1784912331283,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemostatic balance shifted towards hypercoagulability in normal pregnancy is even more pronounced in pre\u2010eclampsia (P\u2010EC). The aim of this study was to analyse haemostatic disturbances and fibrin clot properties in women with pre\u2010eclampsia and to investigate their association with maternal and foetal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010six pregnant women diagnosed with pre\u2010eclampsia were included in the study, with blood sampling done on the morning following admission to hospital, as well as after delivery (mean duration 4.8\u00a0days). Two global haemostatic assays\u2014endogenous thrombin potential (ETP) and assay of overall haemostatic potential (OHP)\u2014were employed, including fibrin clot turbidity measurements and scanning electron microscopy (SEM) of representative samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three thrombin generation parameters (ETP, t_lag and peak height) and OHP were significantly increased in pre\u2010eclampsia compared with controls, whereas overall fibrinolytic potential (OFP\u2014determined as a parameter of the OHP assay) had significantly lower values. Clot lysis time was significantly prolonged in patients with pre\u2010eclampsia. In the pre\u2010eclamptic group after delivery, we observed a significant elevation in the peak height and a reduction in the time to peak and OFP compared with values before delivery. Pre\u2010eclamptic patients with renal complications had significantly higher values for ETP, peak height and D\u2010dimer. Turbidity measurements and SEM revealed dense fibrin structure in patients with pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with pre\u2010eclampsia have enhanced coagulation and impaired fibrinolysis before, and even after, delivery. In particular, the presence of multi\u2010organ dysfunction, such as renal dysfunction, may be associated with increased thrombin generation in pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13183","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T12:03:24Z","timestamp":1584619404000},"page":"322-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of global haemostatic assays and fibrin structure in patients with pre\u2010eclampsia"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-0659","authenticated-orcid":false,"given":"Sanja","family":"Lalic\u2010Cosic","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Pharmacy University of Belgrade Belgrade 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