{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:12:43Z","timestamp":1784027563665,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to review the interfering effect of DOACs on tests for haemostatic function and then to discuss overcoming these with activated carbon (AC) products, thereby eliminating DOAC issues from test plasmas. Recent relevant articles were reviewed and are discussed. Laboratory tests for DOACs, lupus anticoagulant, factor assays and APC Resistance were carried out in such publications with and without an AC product on various instruments using reagents approved for diagnostic use in well\u2010regulated clinical laboratories. All reports on this plasma pre\u2010treatment by AC products agree that they extract DOACs from plasma samples with minimal effect on underlying clotting tests. The specific extraction of DOACs significantly reduced false positive lupus anticoagulant detection and provided more reliable results in clotting factor assays, APC resistance and other thrombophilia tests. Dabigatran and edoxaban seem to be adsorbed more thoroughly by AC from plasmas than rivaroxaban and apixaban. In summary, most of the AC products reviewed here appear to remove DOACs from test plasmas without significantly affecting underlying clotting tests and permit correct diagnosis of various haemostatic conditions despite the initial presence of DOACs. The application of such agents as a sample pre\u2010treatment to overcome the effects of DOACs for routine coagulation testing is supported by the emerging literature.<\/jats:p>","DOI":"10.1111\/ijlh.13196","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:29:01Z","timestamp":1592267341000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The effect of DOACs on laboratory tests and their removal by activated carbon to limit interference in functional assays"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-7669","authenticated-orcid":false,"given":"Thomas","family":"Exner","sequence":"first","affiliation":[{"name":"Haematex Research Lab Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Rigano","sequence":"additional","affiliation":[{"name":"Haematology Department Alfred Hospital Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel J.","family":"Favaloro","sequence":"additional","affiliation":[{"name":"Laboratory Haematology Institute of Clinical Pathology and Medical Research (ICPMR) NSW Health Pathology Westmead Hospital Sydney NSW Australia"},{"name":"Sydney Centres for Thrombosis and Haemostasis Westmead Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"e_1_2_20_2_1","first-page":"491","article-title":"Interference of direct oral anticoagulants in haemostasis assays: high potential for diagnostic false positives and false negatives","volume":"15","author":"Favaloro EJ","year":"2017","journal-title":"Blood Transfus"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-04-791541"},{"key":"e_1_2_20_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.07.101"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01570213"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.01.047"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12807"},{"key":"e_1_2_20_8_1","first-page":"3202","article-title":"Evaluation of the DOAC Stop procedure to overcome the effect of DOACs on several thrombophilia screening tests","volume":"2","author":"Favresee J","year":"2018","journal-title":"TH Open"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.08.014"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16091"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14488"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.05.013"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12950"},{"key":"e_1_2_20_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2018-1197"},{"key":"e_1_2_20_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.11.001"},{"key":"e_1_2_20_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029619872556"},{"key":"e_1_2_20_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-0650"},{"key":"e_1_2_20_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1627480"},{"key":"e_1_2_20_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.08.1462"},{"key":"e_1_2_20_20_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-11-0842"},{"key":"e_1_2_20_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13050"},{"key":"e_1_2_20_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25606"},{"key":"e_1_2_20_23_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPAU7OQM0SRPZQ"},{"key":"e_1_2_20_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028013509074"},{"key":"e_1_2_20_25_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-01-0050"},{"key":"e_1_2_20_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.06.034"},{"key":"e_1_2_20_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25669"},{"key":"e_1_2_20_28_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-1240"},{"key":"e_1_2_20_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2015.11.025"},{"key":"e_1_2_20_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0000000000000252"},{"key":"e_1_2_20_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0245"},{"key":"e_1_2_20_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317711773"},{"key":"e_1_2_20_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12974"},{"key":"e_1_2_20_34_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2018-0967"},{"key":"e_1_2_20_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13486"},{"key":"e_1_2_20_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.04.028"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijlh.13196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.13196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijlh.13196","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.13196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T03:10:40Z","timestamp":1693883440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.13196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":35,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/ijlh.13196"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.13196","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"2020-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}