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Genomic investigations into inherited TMAs are of diagnostic, prognostic and therapeutic value. Here, we present two cases that capture the importance of performing genomic testing in rare disorders. Treatment options for these conditions, such as plasma exchange and monoclonal antibodies against complement factors, are intensive and expensive health care interventions. The results of genomic investigation into rare TMAs can better inform the clinicians and their patients of prognosis and suitable personalized treatment options.<\/jats:p>","DOI":"10.1111\/ijlh.13201","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:29:01Z","timestamp":1592267341000},"page":"33-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genomic investigation of inherited thrombotic microangiopathy\u2014aHUS and TTP"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-090X","authenticated-orcid":false,"given":"Anoop K.","family":"Enjeti","sequence":"first","affiliation":[{"name":"NSW Health Pathology North John Hunter Campus New Lambton Heights NSW Australia"},{"name":"Calvary Mater Newcastle Waratah NSW Australia"},{"name":"School of Medicine and Public Health University of Newcastle Callaghan NSW Australia"},{"name":"Hunter 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