{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:34:08Z","timestamp":1767918848778,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Bendamustine has been reported to be effective against low\u2010grade B\u2010cell lymphoma. We examined the effect of bendamustine on the lymphocyte\u2010monocyte ratio (LMR) in low\u2010grade B\u2010cell lymphoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed 127 cases of first line or relapse\/refractory low\u2010grade B\u2010cell lymphoma in three individual institutions (Asahikawa Municipal Hospital, Aiiku Hospital, and Hakodate Municipal Hospital). Only patients who had received at least three courses of bendamustine therapy were selected; the LMR was evaluated at starting the initial course of bendamustine therapy. Time to next treatment (TTNT) was used to ascertain the efficacy of bendamustine therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follicular lymphoma (FL), at 68.5% (87\/127), is the most common histological subtype of low\u2010grade B\u2010cell lymphoma. The receiver operating characteristic (ROC) curve for the LMR showed a cutoff value of 2.0, and 33 cases (26.0%) had an LMR \u22642.0. Cases with LMR \u22642.0 had a significantly earlier progression than those with LMR\u00a0&gt;\u00a02.0, based on the TTNT (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0007). Additionally, LMR \u22642.0 indicates earlier progression in TTNT when comparing only FL and low\u2010grade B\u2010cell lymphoma cases without FL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.007, 0.002). For multivariate analysis, the factors associated with an LMR \u22642.0 (HR, 2.741; 95% CI, 1.4330\u20105.245; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) were considered as early progression factors with regard to the TTNT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lymphocyte\u2010monocyte ratio effectively predicts the efficacy of bendamustine therapy for low\u2010grade B\u2010cell lymphoma, particularly FL; its application may improve treatment strategies for this disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13216","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T14:51:00Z","timestamp":1588085460000},"page":"431-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lymphocyte\u2010monocyte ratio (LMR) can predict bendamustine therapeutic efficacy in low\u2010grade B\u2010cell 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