{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:57:03Z","timestamp":1768269423925,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M664008"],"award-info":[{"award-number":["2019M664008"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Characteristics of blood coagulation and its relation to clinical outcomes in COVID\u201019 patients are still rarely reported. We aimed to investigate the blood coagulation function and its influences on clinical outcomes of patients with syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 71 severe patients with confirmed SARS\u2010CoV\u20102 infection who were treated in Wuhan First Hospital from February 12 to March 20, 2020, were enrolled. The blood coagulation data in these patients and in 61 healthy controls were collected. The patients with COVID\u201019 were divided into two groups: the aggravated group and the nonaggravated group, respectively, basing on whether the patients' conditions turned to critically ill or not after admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy controls, patients with COVID\u201019 had significant performances with coagulation dysfunction, including dramatically elevated values of FIB, PT, APTT, INR, FDP, and D\u2010Dimers but markedly reduced AT value (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Importantly, more noteworthy coagulation disorders similar to the differences between patients and controls were found in the aggravated patients with conditions deterioration after admission than those in the nonaggravated patients without conditions deterioration (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Moreover, the aggravated patients possessed a longer hospital stay and a higher mortality compared with the nonaggravated patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The coagulation parameters of COVID\u201019 patients were widely and closely related to the indexes of liver function and inflammation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), indicating the coagulation dysfunction of these patients may be caused by liver injury and inflammatory storm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Severe patients with SARS\u2010CoV\u20102 infection often possess coagulation dysfunction on admission. A certain correlation exists in coagulation disorder and adverse clinical outcome among severe COVID\u201019 patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13273","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T14:44:41Z","timestamp":1593269081000},"page":"766-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Manifestations of blood coagulation and its relation to clinical outcomes in severe COVID\u201019 patients: Retrospective analysis"],"prefix":"10.1111","volume":"42","author":[{"given":"Yanhong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Transfusion Wuhan First Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Transfusion Wuhan First Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huixin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Transfusion Wuhan First Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Transfusion Wuhan First Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfen","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Transfusion Wuhan First Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Transfusion Wuhan First Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Transfusion Wuhan First Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Transfusion Wuhan First Hospital Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-3260","authenticated-orcid":false,"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Transfusion General Hospital of Central Theater Command of the PLA Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2648"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14768"},{"key":"e_1_2_7_8_1","unstructured":"World Health Organization.Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance. 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