{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:06:48Z","timestamp":1759741608459,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Adult T\u2010cell leukemia\/lymphoma (ATLL) is a malignant peripheral T\u2010cell neoplasm associated with human T\u2010cell leukemia virus type\u20101 (HTLV\u20101). The acute and lymphoma subtypes are regarded as aggressive ATLLs, and the overall survival (OS) of patients remains poor. Transforming acidic coiled\u2010coil\u2010containing protein 3 (TACC3) regulates microtubules, which are associated with cancer\u2010related proteins overexpressed in various cancers. Such a relationship has not been reported in hematopoietic tumors, including ATLL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined tissue microarrays of histological samples from 92 cases of aggressive ATLL and assessed clinical features, including TACC3 protein expression levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with TACC3\u2010low, TACC3\u2010high ATLL patients were significantly older (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), with a tendency toward pleomorphic variant over other morphological classifications (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.019). TACC3\u2010high patients (median survival time [MST] 10.6\u00a0months, confidence interval [CI] [6.27\u201015.6]) had poorer OS compared to TACC3\u2010low patients (MST 20\u00a0months, CI [9.43\u201038.5]) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0168). Moreover, multivariate analysis on TACC3 expression levels suggests that TACC3\u2010high is an independent significant prognostic factor (HR, 1.700; 95% CI, 1.037\u20102.753; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0355).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Certain drugs that inhibit TACC3\u2010overexpressing neoplastic cells are used clinically. Further studies might highlight a key role for TACC3 in the oncogenesis and progression of ATLL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13289","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T16:00:48Z","timestamp":1596470448000},"page":"842-848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["TACC3 expression as a prognostic factor in aggressive types of adult T\u2010cell leukemia\/lymphoma patients"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3382-0473","authenticated-orcid":false,"given":"Mayuko","family":"Moritsubo","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University School of medicine Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of 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