{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:17:15Z","timestamp":1747185435223,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T00:00:00Z","timestamp":1600473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In 2015, Sysmex launched a new series of hematology analyzers (XN\u2010L Series) designed to fulfill the needs of niche laboratories in areas such as pediatrics, dialysis, neurology, and oncology while providing a compact solution. In this study, we evaluate the whole blood and body fluid modes of one of these analyzers, the XN\u2010350.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 300 residual EDTA samples were measured on the XN\u2010350 in whole blood mode and the XN\u20101000 to evaluate method comparison, flagging sensitivity, repeatability, reproducibility, linearity, carryover, and stability. In addition, 191 samples were obtained and processed in body fluid mode which included, cerebrospinal fluid (CSF), continuous ambulatory peritoneal dialysis (CAPD), ascites, synovial, and pleural fluid to perform method comparison, repeatability, reproducibility, linearity, limit of quantitation, and carryover studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Strong agreement was shown between the XN\u2010350 and XN\u20101000 for both whole blood and body fluid modes in results and flagging. Linearity results in both modes on the XN\u2010350 showed a high <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> value (&gt;.99). For WBC, RBC, HGB, and PLT, the carryover results were well within the predetermined criteria of \u22640.5% for whole blood and \u22640.3% for CSF. Repeatability and reproducibility were acceptable for both modes, and there were no significant deviations present in stability for whole blood. In addition, there was high agreement in all body fluid types evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The performance of the XN\u2010350 is comparable to the XN\u20101000 in both whole blood and body fluid modes, making it a reliable alternative to larger analyzers for smaller, niche laboratories.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13339","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T15:06:45Z","timestamp":1600528005000},"page":"29-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Sysmex XN\u2010L (XN\u2010350) hematology analyzer offers a compact solution for laboratories in niche diagnostics"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-1710","authenticated-orcid":false,"given":"Tania A.","family":"Khartabil","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry Erasmus MC, University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda M.","family":"de Frankrijker","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Erasmus MC, University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-4968","authenticated-orcid":false,"given":"Yolanda B.","family":"de Rijke","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Erasmus MC, University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7289-7572","authenticated-orcid":false,"given":"Henk","family":"Russcher","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Erasmus MC, University Medical Center Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,19]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"63","article-title":"The automated hematology analyzers","volume":"24","author":"Kaznowska\u2010Bystryk I","year":"2011","journal-title":"Ann Univ Mariae Curie\u2010Sklowdowska"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-5535-03-00023-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1309\/AXXV-56JD-0F64-F5LD"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-200930"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0927"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2014-1247"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12254"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21938"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12372"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12436"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12701"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12617"},{"key":"e_1_2_7_13_1","first-page":"115","article-title":"High fluorescence cell count in pleural fluids for malignant effusion screening","volume":"499","author":"Wong\u2010Arteta J","year":"2019","journal-title":"Int J Lab Hematol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2020.40.2.122"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1532\/LH96.05019"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12201"},{"key":"e_1_2_7_17_1","unstructured":"ISO \u2010 ISO 5725\u20136:1994 \u2010 Accuracy (trueness and precision) of measurement methods and results \u2014 Part 6: Use in practice of accuracy values.https:\/\/www.iso.org\/standard\/11837.html"},{"key":"e_1_2_7_18_1","unstructured":"Sysmex Europe GmbH. XN\u2010350[Sysmex Website].http:\/\/www.sysmex\u2010europe.com\/products\/xn\u2010350\u20103478.html"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-0155"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141311"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.033787"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.01.012"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.13339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijlh.13339","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.13339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T08:38:56Z","timestamp":1693730336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.13339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,19]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/ijlh.13339"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.13339","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"type":"print","value":"1751-5521"},{"type":"electronic","value":"1751-553X"}],"subject":[],"published":{"date-parts":[[2020,9,19]]},"assertion":[{"value":"2020-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}