{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:33:10Z","timestamp":1783625590256,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of structural abnormalities in high hyperdiploidy (HeH) has been debatable, with few studies that addressed recurrent translocations with concurrent HeH (t\u2010HeH). We aimed at the characterization of HeH cases in pediatric B\u2010acute lymphoblastic leukemia (B\u2010ALL) patients with special emphasis on the structural abnormalities including t\u2010HeH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Our study included all patients diagnosed with HeH over the period from January 2016 to April 2019 presenting to the Pediatric Oncology Department, National Cancer Institute, Cairo University.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 480 de novo B\u2010ALL pediatric patients, HeH was detected in eighty (16.7%) cases with a median age of 5\u00a0years. t\u2010HeH was identified in 17\/480 (3.5%) cases: 9(1.9%) with t(12;21), 7(1.5%) with t(9;22), and 1(0.2%) with t(4;11). Duplication (1q) was the most prevalent structural abnormality in c\u2010HeH (hyperdiploidy without recurrent translocations) (n\u00a0=\u00a012,15%). Children \u226510\u00a0years or presenting with white blood cells (WBC) \u226550\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L) had an inferior 3\u00a0year\u2010overall survival as compared to younger children (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003), and to lower WBC (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). Duplication (1q) was an independent adverse parameter on the disease\u2010free survival (DFS) of c\u2010HeH patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Older age and WBC\u00a0\u2265\u00a050\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/L were adverse prognostic factors. Duplication (1q) is correlated with lower DFS in c\u2010HeH patients. t\u2010HeH has distinct patterns of chromosomal gain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13369","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T17:50:45Z","timestamp":1603129845000},"page":"235-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Duplication 1q is highly correlated with poor prognosis in high hyperdiploid pediatric B\u2010acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"43","author":[{"given":"Mona S.","family":"El Ashry","sequence":"first","affiliation":[{"name":"Clinical Pathology Department National Cancer Institute Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada M.","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department National Cancer Institute Cairo University Cairo 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