{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:09:15Z","timestamp":1785460155342,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Infant iron status assessments may be difficult to interpret due to infections. The soluble transferrin receptor (sTfR) has been suggested as a biomarker mainly unaffected by the acute phase response. Reference intervals reflecting dynamics of infant growth first year in life are not well established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sTfR and CRP concentrations were measured in samples from 451 term infants with the Roche Cobas platform in umbilical cord, at 48\u201096\u00a0hours, 4 and 12\u00a0months. Reference values were constructed as the 2.5th and 97.5th percentiles. The relationship between CRP concentrations &gt;1\u00a0mg\/L and sTfR was tested by Kendall correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reference intervals for girls and boys were 2.4\u20109.5\u00a0mg\/L at birth, 2.9\u20108.4\u00a0mg\/L at 48\u201096\u00a0hours, 2.6\u20105.7\u00a0mg\/L at 4\u00a0months and 3.0\u20106.3\u00a0mg\/L at 12\u00a0months. No differences between sexes were observed except for at 4\u00a0months. sTfR did not covariate with CRP concentrations &gt;1\u00a0mg\/L except in 48\u201096\u00a0hours samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study reports reference intervals for sTfR from birth to 12\u00a0months of age in a large group of infants in a low\u2010risk area for iron deficiency. sTfR might add value to infant iron status diagnostics since no covariation with CRP was found at birth, at 4\u00a0months or at 12\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13391","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T01:13:42Z","timestamp":1605921222000},"page":"378-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Soluble Transferrin Receptor during infancy and reference intervals for the Roche Cobas 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