{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:20:42Z","timestamp":1792516842031,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Atrial fibrillation (AF) is associated with platelet hyperactivity and a higher proportion of immature platelets. We aimed to examine whether immature platelet fraction (IPF) and inflammatory markers differ between AF types and whether they are affected by ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study included patients with atrial fibrillation\/flutter (AFL). We excluded patients with hematologic, inflammatory, or acute coronary states. Blood samples for IPF, white blood cells (WBC), neutrophil\u2010to\u2010lymphocyte ratio (NLR), and C\u2010reactive protein (CRP) were collected at baseline, within one\u2010hour postablation in those undergoing ablations, and the day after ablation. IPF was measured by an autoanalyzer (Sysmex 2100 XE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and four patients were included (paroxysmal AF\u201063, persistent AF\u201036, AF and AFL\u20107, AFL alone\u20105), (Mean age 67.7\u00a0\u00b1\u00a012.8\u00a0years, 54.8% male, CHA<jats:sub>2<\/jats:sub>D<jats:sub>2<\/jats:sub>\u2010VASC<jats:sub>2<\/jats:sub> 3.2\u00a0\u00b1\u00a01.8). Seventy\u2010two patients underwent ablation (cryoballoon AF ablation\u201060, AFL radiofrequency ablation\u20105, both\u20107). There was no difference between paroxysmal and persistent AF regarding baseline markers. There was a significant change in the following parameters after ablation: WBC (baseline 6.9\u00a0\u00b1\u00a02.0, 1\u2010h post 8.0\u00a0\u00b1\u00a02.4, and 1\u2010day post 9.0\u00a0\u00b1\u00a02.8 \u00d710<jats:sup>9<\/jats:sup>\/L), NLR (2.9\u00a0\u00b1\u00a02.2, 3.0\u00a0\u00b1\u00a02.4, 4.2\u00a0\u00b1\u00a02.9, respectively), and CRP (3.6\u00a0\u00b1\u00a03.7, 3.6\u00a0\u00b1\u00a03.5, 12.4\u00a0\u00b1\u00a09.0\u00a0mg\/L, respectively) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 for all). However, there were no differences in immature platelet count (8.6\u00a0\u00b1\u00a04.8, 8.5\u00a0\u00b1\u00a04.9, 8.4\u00a0\u00b1\u00a05.2 \u00d710<jats:sup>9<\/jats:sup>\/L) or IPF (4.6\u00a0\u00b1\u00a03.2, 4.7\u00a0\u00b1\u00a03.3, 4.9\u00a0\u00b1\u00a03.6%) from baseline to postablation (p\u00a0=\u00a0NS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AF persistency does not affect IPF and inflammation. In patients undergoing cryoablation of AF, there is a postablation inflammatory process; however, platelet activation is probably not affected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13426","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T04:24:19Z","timestamp":1607487859000},"page":"602-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Measurements of immature platelet fraction and inflammatory markers in atrial fibrillation patients \u2010 Does persistency or ablation affect results?"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2529-0975","authenticated-orcid":false,"given":"Olga","family":"Perelshtein Brezinov","sequence":"first","affiliation":[{"name":"Department of Cardiology Assuta Ashdod University Medical Center, Ben\u2010Gurion University of the Negev  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziv","family":"Sevylia","sequence":"additional","affiliation":[{"name":"Department of Cardiology Assuta Ashdod University Medical Center, Ben\u2010Gurion University of the Negev  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rahkovich","sequence":"additional","affiliation":[{"name":"Department of Cardiology Assuta Ashdod University Medical Center, Ben\u2010Gurion University of the Negev  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Kakzanov","sequence":"additional","affiliation":[{"name":"Department of Cardiology Assuta Ashdod University Medical Center, Ben\u2010Gurion University of the Negev  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Yahud","sequence":"additional","affiliation":[{"name":"Department of Cardiology Assuta Ashdod University Medical Center, Ben\u2010Gurion University of the Negev  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Fortis","sequence":"additional","affiliation":[{"name":"Department of Cardiology Assuta Ashdod University Medical Center, Ben\u2010Gurion University of the Negev  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonatan","family":"Kogan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Assuta Ashdod University Medical Center, Ben\u2010Gurion University of the Negev  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Asher","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center Shaare Zedek Medical Center, The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Lev","sequence":"additional","affiliation":[{"name":"Department of Cardiology Assuta Ashdod University Medical Center, Ben\u2010Gurion University of the Negev  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avishag","family":"Laish\u2010Farkash","sequence":"additional","affiliation":[{"name":"Department of Cardiology Assuta Ashdod University Medical Center, Ben\u2010Gurion University of the Negev  Ashdod Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00563.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv326"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1667338"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.01.042"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000876"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-016-1002-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux233"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:JICE.0000026924.96281.be"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum039"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2005.50103.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01468.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13177"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.2016.0172"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_9_17_1","unstructured":"Desirable Biological Variation Database specifications \u2010 Westgard [Internet]. [cited 2020 Nov 1]. Available from: https:\/\/www.westgard.com\/biodatabase1.htm."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2007.00909.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025376605807"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00906-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.09.017"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14475"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2017.12.001"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00324-5"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70257-7"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2019.104105"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000058706.82623.A1"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.13426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijlh.13426","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.13426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T14:18:58Z","timestamp":1693232338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.13426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,8]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/ijlh.13426"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.13426","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,8]]},"assertion":[{"value":"2020-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}