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This study aimed to investigate the possible influence of <jats:italic>FOXP3<\/jats:italic> gene polymorphisms on genetic predisposition to chronic immune thrombocytopenia (ITP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study cohort comprised 329 chronic ITP patients and 279 healthy controls, who were genotyped for three polymorphisms in the promoter region of <jats:italic>FOXP3<\/jats:italic> gene, \u22126054 del\/ATT, \u22123279 A\/C, and \u2212924 A\/G.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the three polymorphisms identified, the \u22123279 AA genotype was more frequent in female patients with chronic ITP than in female controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.035, OR 0.434, 95% CI 0.223\u20100.846), and the \u22123279 A carrier was shown to be associated with the risk of chronic ITP in female cohort (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003, OR 0.610, 95% CI 0.437\u20100.851). Furthermore, the female patients with chronic ITP had remarkably more frequent haplotype \u22126054 del\/\u22123279 A\/\u2212924 A (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.027, OR 3.584, 95% CI 1.148\u201011.186) and less haplotype \u22126054 del\/\u22123279 C\/\u2212924 G (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.039, OR 0.445, 95% CI 0.204\u20100.973) in comparison with female healthy controls. Although there were no significant differences in the male cohort, when the combined alleles and haplotypes of the two genders were analyzed, the results obtained were similar to those of females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to our data, the \u22123279 A\/C polymorphism of <jats:italic>FOXP3<\/jats:italic> gene may be associated with the susceptibility to chronic ITP in Chinese Han population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13525","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T08:49:41Z","timestamp":1616575781000},"page":"1104-1109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of <i>FOXP3<\/i> gene polymorphisms with chronic immune thrombocytopenia in a Chinese Han population"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-0439","authenticated-orcid":false,"given":"Donglei","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology National Clinical Research Center for Hematological disorders Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of hematology Zhongnan hospital of Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyuan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology National Clinical Research Center for Hematological disorders Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"CAMS Key Laboratory of Gene Therapy for Blood Diseases Tianjin China"},{"name":"Tianjin Laboratory of Blood Disease Gene Therapy Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology National Clinical Research Center for Hematological disorders Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"},{"name":"CAMS Key Laboratory of Gene Therapy for Blood Diseases Tianjin China"},{"name":"Tianjin Laboratory of Blood Disease Gene Therapy Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology National Clinical Research Center for Hematological disorders Institute of 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