{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:44:15Z","timestamp":1790246655282,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hodgkin lymphoma (HL) is unusual among malignancies, with inflammation playing such a prominent role in its pathogenesis. S100A8\/A9 (calprotectin) is a heterodimeric protein, which has a role in the inflammatory response and oncogenesis. In this study in HL patients, the correlation between serum S100A8\/A9 levels and treatment responses was investigated along with whether this marker is correlated with other inflammatory markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Thirty\u2010three HL patients and 20 healthy volunteers were included. Demographic and clinical characteristics were recorded. Calprotectin levels were measured with Human S100A8\/A9 Heterodimer Quantikine ELISA kit. Calprotectin levels were measured twice in patients, before and after treatment, and once in the control group. Treatment responses were evaluated with positron emission tomography\u2010computed tomography (PET\u2010CT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of patients was 44.3\u00a0\u00b1\u00a018.1 (66.3% male). The median (IQR) values of S100A8\/A9 before and after treatment in the patient group were 4.98 (2.6\u20107.8) and 1.87 (1.1\u20104.8)\u00b5g\/mL. Median (IQR) S100A8\/A9 concentration in the control group was 1.41 (0.98\u20102.73)\u00b5g\/mL. In patients, pretreatment values were significantly higher than in controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). However, median values of patients after treatment and controls were similar. Patient median S100A8\/A9 levels were significantly lower post\u2010treatment compared with pretreatment values (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001). When inflammatory markers were examined within groups, no relationship was found between markers. In ROC analysis, a S100A8\/A9 cutoff value of \u22653.31\u00b5g\/mL accurately discriminated end\u2010of\u2010treatment PET positivity (AUC\u00a0=\u00a00.78; 95% CI 0.58\u20100.98; accuracy\u00a0=\u00a076.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>S100A8\/A9 may be a potential biomarker for treatment response in HL independent of inflammation. This is the first study to investigate and show this finding. However, further large\u2010scale studies are still required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.13559","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T14:43:37Z","timestamp":1619534617000},"page":"638-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Serum calprotectin (S100A8\/A9) levels as a new potential biomarker of treatment response in Hodgkin lymphoma"],"prefix":"10.1111","volume":"43","author":[{"given":"\u015eeyma","family":"\u015eumnu","sequence":"first","affiliation":[{"name":"Department of Hematology Medical Faculty University of Kocaeli  Kocaeli Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Mehtap","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical Faculty University of Kocaeli  Kocaeli 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