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MPN can transform into an accelerated or a blast phase, which is associated with poor response to standard therapy and low overall median survival. We present an interesting case of a patient with a history of PMF and progression and summarize the current studies on genetic features of myeloproliferative neoplasms in blast phase (MPN\u2010BP) with an emphasis on PMF. Although MPN\u2010BP show \u226520% blasts in peripheral blood or bone marrow, it is not considered as acute myeloid leukemia (AML) according to the WHO classification. While MPNs\u2010BP typically lack genetic mutations seen in de novo AML, they commonly harbor <jats:italic>IDH1\/2, SRSF2, ASXL1,<\/jats:italic> and <jats:italic>TP53<\/jats:italic> mutations<jats:italic>,<\/jats:italic> similar to the genetic profiles of acute myeloid leukemia with myelodysplasia\u2010related changes (AML\u2010MRC).<\/jats:p>","DOI":"10.1111\/ijlh.13565","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:50:39Z","timestamp":1626828639000},"page":"78-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of a primary myelofibrosis with progression and related literature review of progression phase genetics"],"prefix":"10.1111","volume":"43","author":[{"given":"Dong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center  Dallas TX 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