{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T06:39:18Z","timestamp":1770532758682,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the prevalence of early T precursor\u2010acute lymphoblastic leukaemia (ETP\u2010ALL), study its clinicopathological features and devise a \u2018flow score\u2019 based on immunophenotypic profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material Methods<\/jats:title><jats:p>This was a retrospective study where clinical and laboratory data of all consecutive T\u2010ALL cases were analysed to identify features differentiating ETP from non\u2010ETP\u2010ALL. The utility of a flow score based on the five commonly used markers in leukaemia panels for T\u2010ALL (CD34, CD8, CD5, CD13 and CD33) was evaluated to differentiate ETP from non\u2010ETP\u2010ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Early T precursor\u2010acute lymphoblastic leukaemia constituted 24.2% (n\u00a0=\u00a029) of all T\u2010ALL cases. It was significantly more common in adults (30.2%) as compared to paediatric (17.5%) patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.046). The median age of presentation was significantly higher than the non\u2010ETP group. (24 vs 19\u00a0years; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Patients with ETP\u2010ALL usually presented with organomegaly, lymphadenopathy, lower levels of haemoglobin, total leucocyte count, peripheral blood blast proportion and LDH levels as compared to non\u2010ETP\u2010ALL. The majority of ETP\u2010ALL cases had L2 morphology with a moderate amount of cytoplasm showing frequent blebbing. A flow score cut\u2010off value of \u22653 on ROC curve analysis had a sensitivity and specificity of 100% and 94.6% respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early T precursor\u2010acute lymphoblastic leukaemia had unique clinical and laboratory features. The prevalence of this entity is more common in the adult population. A flow score based on a minimum of five widely used markers can confidently identify ETP\u2010ALL and should be included in the primary panel of markers used for flow cytometric analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13621","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T16:55:48Z","timestamp":1623430548000},"page":"1417-1423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinicopathological and immunophenotypic features of early T cell precursor acute lymphoblastic leukaemia: A flow cytometry score for the initial diagnosis"],"prefix":"10.1111","volume":"43","author":[{"given":"Dinesh","family":"Chandra","sequence":"first","affiliation":[{"name":"Department of Hematology SGPGIMS Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-2656","authenticated-orcid":false,"given":"Manish 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