{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:27:17Z","timestamp":1789241237685,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:00:00Z","timestamp":1625270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The current study aimed to describe genotypes associated with Hodgkin lymphoma (HL) in a cohort of Saudi and non\u2010Saudi patients and discuss their possible susceptibility to HL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied clinical, histopathological, and laboratory findings of HL patients admitted over 12\u00a0years duration, at King Fahd University Hospital, KSA. The genomic DNAs of HL patients (n\u00a0=\u00a061) and normal control subjects (n\u00a0=\u00a036) were extracted, and genotyping was performed using the Illumina human exome bead chip. Set of HL patients and set of normal controls were included in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 35 DNA variants were found to be highly significant with the <jats:italic>P<\/jats:italic>\u2010value &lt;9.90\u00a0\u00d7\u00a010<jats:sup>\u221211<\/jats:sup> among 243\u00a0345 exonic biomarkers and obeying the Hardy\u2010Weinberg equilibrium. Nine, <jats:italic>MEGF11\u2010rs150945752<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2010value 1.20\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>)<jats:italic>, CACNA1I\u2010 s58055559<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2010value 1.93\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>)<jats:italic>, DECR2\u2010<\/jats:italic>rs146760080 (<jats:italic>P<\/jats:italic>\u2010value 2.19\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>), <jats:italic>STAB1\u2010<\/jats:italic>rs143894786 (<jats:italic>P<\/jats:italic>\u2010value 2.45\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>), <jats:italic>ZNF526\u2010<\/jats:italic>rs144433879 (<jats:italic>P<\/jats:italic>\u2010value 2.76\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>), <jats:italic>CPLANE1\u2010<\/jats:italic>rs200612080 (<jats:italic>P<\/jats:italic>\u2010value 3.77\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>), <jats:italic>DLK1\u2010<\/jats:italic>rs1058009 (<jats:italic>P<\/jats:italic>\u2010value 5.95\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>), <jats:italic>RTN4RL2\u2010<\/jats:italic>rs61745214 (<jats:italic>P<\/jats:italic>\u2010value 7.71\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>), and <jats:italic>PGRMC1\u2010<\/jats:italic>rs145582672 (<jats:italic>P<\/jats:italic>\u2010value 8.56\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>), exonic variants on chromosomes 15, 22, and 16 were highly associated with HL cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>The highly significant haplotypes at chromosome 3<\/jats:title><jats:p>rs143894786G; rs149982219G with <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a03.43\u00a0\u00d7\u00a010<jats:sup>\u221214<\/jats:sup> was found to be the risk haplotype for the HL patients. The opposite alleles at chromosome 3: rs143894786A; rs149982219G is protective with <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a02.46\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>. Maximum number of SNPs at the chromosome 19: rs144433879C; rs181265966G; rs201144421C; rs145591797G; rs200560875G; rs77270337G (risk <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a02.24\u00a0\u00d7\u00a010<jats:sup>\u221212<\/jats:sup>) and its opposite allele rs144433879A; rs181265966A; rs201144421T; rs145591797A; rs200560875A; rs77270337A (protective <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a02.60\u00a0\u00d7\u00a010<jats:sup>\u22129<\/jats:sup>) were found to be associated haplotype with the HL and controls, respectively, in Saudi population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study concludes that the HL is genetically heterogeneous with multigene causation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13644","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T15:44:35Z","timestamp":1625327075000},"page":"1472-1482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Functional multigenic variations associated with hodgkin lymphoma"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5054-2666","authenticated-orcid":false,"given":"Yasser","family":"Osman","sequence":"first","affiliation":[{"name":"Pathology Department College of Medicine Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Elsharkawy","sequence":"additional","affiliation":[{"name":"Pathology Department College of Medicine Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq Mohammad","family":"Hashim","sequence":"additional","affiliation":[{"name":"Pathology Department College of Medicine Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumana Abdulwahab","family":"Alratroot","sequence":"additional","affiliation":[{"name":"Pathology Department College of Medicine Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hind Saleh","family":"Alsuwat","sequence":"additional","affiliation":[{"name":"Department of Genetic Research Institute for Research and Medical Consultations (IRMC) Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waad Mohammed Al","family":"Otaibi","sequence":"additional","affiliation":[{"name":"Department of Genetic Research Institute for Research and Medical Consultations (IRMC) Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Mohammed","family":"Hegazi","sequence":"additional","affiliation":[{"name":"Department of Genetic Research Institute for Research and Medical Consultations (IRMC) Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed","family":"AbdulAzeez","sequence":"additional","affiliation":[{"name":"Department of Genetic Research Institute for Research and Medical Consultations (IRMC) Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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