{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:34:01Z","timestamp":1768869241882,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Developing prognostic markers can be useful for clinical decision\u2010making. Peripheral blood (PB) examination is simple and basic that can be performed in any facility. We aimed to investigate whether PB examination can predict prognosis in coronavirus disease (COVID\u201019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Complete blood count (CBC) and PB cell morphology were examined in 38 healthy controls (HCs) and 40 patients with COVID\u201019. Patients with COVID\u201019, including 26 mild and 14 severe cases, were hospitalized in Juntendo University Hospital (Tokyo, Japan) between April 1 and August 6, 2020. PB examinations were performed using Sysmex XN\u20103000 automated hematology analyzer and Sysmex DI\u201060 employing the convolutional neural network\u2010based automatic image\u2010recognition system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with mild cases, severe cases showed a significantly higher incidence of anemia, lymphopenia, and leukocytosis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Granular lymphocyte counts were normal or higher in mild cases and persistently decreased in fatal cases. Temporary increase in granular lymphocytes was associated with survival of patients with severe infection. Red cell distribution width was significantly higher in severe cases than in mild cases (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Neutrophil dysplasia was consistently observed in COVID\u201019 cases, but not in HCs. Levels of giant neutrophils and toxic granulation\/D\u00f6hle bodies were increased in severe cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Basic PB examination can be useful to predict the prognosis of COVID\u201019, by detecting SARS\u2010CoV\u20102 infection\u2010induced multi\u2010lineage changes in blood cell counts and morphological anomalies. These changes were dynamically correlated with disease severity and may be associated with disruption of hematopoiesis and the immunological system due to bone marrow stress in severe infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13696","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T10:57:19Z","timestamp":1631703439000},"page":"1309-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Peripheral granular lymphocytopenia and dysmorphic leukocytosis as simple prognostic markers in COVID\u201019"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2191-5405","authenticated-orcid":false,"given":"Yuki","family":"Horiuchi","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine Juntendo University Graduate School of Medicine Bunkyo\u2010ku 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