{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:19Z","timestamp":1787014339040,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Health professions are heavily engaged facing the current threat of SARS\u2010CoV\u20102 (COVID\u201019). Although there are many diagnostic tools, an accurate and rapid laboratory procedure for diagnosing COVID\u201019 is recommended. We focused on platelet parameters as the additional biomarkers for clinical diagnosis in patients presenting to the emergency department (ED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Five hundred and sixty\u2010one patients from February to April 2020 have been recruited. Patients were divided into three groups: (N\u00a0=\u00a050) COVID\u201019 positive and (N\u00a0=\u00a021) COVID\u201019 negative with molecular testing, (N\u00a0=\u00a0490) as reference population without molecular testing. A Multiplex rRT\u2010PCR from samples collected by nasopharyngeal swabs was performed and the hematological data collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We detected a mild anemia in COVID\u201019 group and lymphopenia against reference population: hemoglobin (g\/dL) 13.0 (11.5\u201014.8) versus 13.9 (12.8\u201015.0) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0135); lymphocytes (10\n                      <jats:sup>9<\/jats:sup>\n                      \/L) 1.24 (0.94\u20101.73) versus 1.99 (1.49\u20102.64) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001). In addition, abnormal platelet parameters as follows (COVID group vs reference population): PLT (\u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L) 209 (160\u2010258) vs 236 (193\u2010279) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0239). IPF (%) 4.05 (2.5\u20105.9) versus 3.4 (2.2\u20104.9) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0576); H\u2010IPF (%) 1.25 (0.8\u20102.2) versus 0.95 (0.6\u20101.5) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0171) were identified. In particular, COVID positive group had a high H\u2010IPF\/IPF Ratio compared to reference population [0.32 (0.29\u20100.36) versus 0.29 (0.26\u20100.32), respectively, (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0003)]. Finally, a PLT difference of nearly 50\u00a0\u00d7\u00a010\n                      <jats:sup>9<\/jats:sup>\n                      \/L between pre\/postCOVID\u201019 sampling for each patient was found (N\u00a0=\u00a042) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.0194).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>COVID\u201019 group results highlighted higher IPF and H\u2010IPF values, with increased H\u2010IPF\/IPF Ratio, associated to PLT count reduction. These findings shall be adopted for a timely diagnosis of patients upon hospital admission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.13701","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T12:55:52Z","timestamp":1631883352000},"page":"1319-1324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["High immature platelet fraction with reduced platelet count on hospital admission. Can it be useful for COVID\u201019 diagnosis?"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-8696","authenticated-orcid":false,"given":"Giovanni","family":"Introcaso","sequence":"first","affiliation":[{"name":"Unit of Laboratory Medicine Centro Cardiologico IRCCS Monzino Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Bonomi","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics Centro Cardiologico IRCCS Monzino Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Salvini","sequence":"additional","affiliation":[{"name":"Emergency Department Centro Cardiologico IRCCS Monzino Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"D\u2019Errico","sequence":"additional","affiliation":[{"name":"Unit of Laboratory Medicine Centro Cardiologico IRCCS Monzino Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Unit of Laboratory Medicine Centro Cardiologico IRCCS Monzino Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Assanelli","sequence":"additional","affiliation":[{"name":"Emergency Department Centro Cardiologico IRCCS Monzino Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Stella","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Unit of Brain\u2010Heart Axis Centro Cardiologico IRCCS Monzino Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Biondi","sequence":"additional","affiliation":[{"name":"Unit of Laboratory Medicine Centro Cardiologico IRCCS Monzino Milan 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