{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T13:46:34Z","timestamp":1781444794502,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) caused by SARS\u2010CoV2 can present from mild flu\u2010like symptoms to acute respiratory distress syndrome. There is multi\u2010organ involvement; particularly, hematopoietic system can be associated with morphological changes in blood cells of COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We conducted a cross\u2010sectional study on a cohort of 50 COVID\u201019 patients, confirmed on RT\u2010PCR with documented cycle threshold (Ct) value. Peripheral blood sample of these patients was collected and examined for complete blood counts (CBC) on automated haematological analyser as well as Leishman\u2010stained blood smears to look for morphological changes in blood cells. Morphological changes were evaluated with reference to clinical severity and Ct value. Additionally, association between Ct value and clinical severity was also performed. Statistical tests were performed, and <jats:italic>P<\/jats:italic> value &lt;.05 was considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age of our study group was 42.16\u00a0\u00b1\u00a015.55\u00a0years, with male preponderance. Most commonly observed peripheral blood changes were hypolobation (<jats:italic>P<\/jats:italic> value\u00a0=\u00a0.002) and toxic granules (<jats:italic>P<\/jats:italic> value\u00a0=\u00a0.005) in neutrophils, atypical granules with nucleolar prominence in lymphocytes, cytoplasmic granulation with clumped nuclear chromatin in monocytes, giant platelets and thrombocytopenia and normocytic normochromic anaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No association was found between clinical severity and Ct value as well as peripheral blood morphological changes with Ct value. We conclude that examination of peripheral smear coupled with complete blood count (CBC) is only partially supportive of disease pathogenesis and to assess the viral load other parameters should be utilised instead of relying solely on Ct value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13720","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T20:11:32Z","timestamp":1633119092000},"page":"1334-1340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Changes in peripheral blood in SARS CoV\u20102 patients and its clinico\u2010pathological correlation: A prospective cross\u2010sectional study"],"prefix":"10.1111","volume":"43","author":[{"given":"Shalini","family":"Bahadur","sequence":"first","affiliation":[{"name":"Department of Pathology Government Institute of Medical Sciences Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Kalonia","sequence":"additional","affiliation":[{"name":"Department of Pathology Government Institute of Medical Sciences Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan","family":"Kamini","sequence":"additional","affiliation":[{"name":"Department of Pathology National Institute of Medical Sciences Jaipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-958X","authenticated-orcid":false,"given":"Bhumika","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology Government Institute of Medical Sciences Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Kalhan","sequence":"additional","affiliation":[{"name":"Department of Pathology Government Institute of Medical Sciences Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Jain","sequence":"additional","affiliation":[{"name":"Paras Hospital Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organisation Novel coronavirus (COVID\u201019) situation.http:\/\/covid19.who.int\/. 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