{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:29:08Z","timestamp":1760956148639,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["121943"],"award-info":[{"award-number":["121943"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Increased antiphospholipid antibodies (aPL) have been described in human immunodeficiency virus (HIV) infection. However, the association between aPL and the increased risk of thrombosis in HIV requires further clarification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the medical records of 215 consecutive women with a history of thrombosis and\/or obstetric complications (158 HIV\u2010uninfected and 57 HIV\u2010infected) between July 2017 and March 2021. Participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a0215) without clinical criteria manifestations for antiphospholipid syndrome were included as matched controls. Testing for lupus anticoagulant (LAC), anticardiolipin (aCL) and anti\u2010beta2\u2010glycoprotein1 (a\u03b22GP1) IgM and IgG was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two (10.1%) HIV\u2010uninfected and 15 (13.2%) HIV\u2010infected participants were positive at baseline for one of the five criteria aPL, with no statistically significant difference. The profile of the HIV\u2010infected participants with thrombosis (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) included LAC in 15.8%, aCL IgG in 3.5% and a\u03b22GP1 IgG in 1.8%. In contrast, the HIV\u2010infected controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), included aCL IgM in 1.8% and a\u03b22GP1 IgM in 5.3%. Only LAC was significantly associated with thrombosis (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.003). On repeat testing, in a HIV\u2010infected sub\u2010population, 2\/7 with thrombosis were positive, while 3\/3 controls tested negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In contrast to earlier reports, the prevalence and expression of aPL in HIV\u2010infected women with a history of thrombosis in the present study, in the era of antiretroviral therapy, were similar to HIV\u2010uninfected women. Baseline LAC positivity was associated with a significantly increased risk for thrombosis in HIV. Future studies are recommended to explore additional coagulation abnormalities in HIV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13805","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T04:33:36Z","timestamp":1644294816000},"page":"635-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Profile of antiphospholipid antibodies in HIV\u2010infected and HIV\u2010uninfected women with a history of thrombosis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-2930","authenticated-orcid":false,"given":"Elise","family":"Schapkaitz","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Haematology Faculty of Health Sciences University of Witwatersrand Medical School Johannesburg South 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