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Preimplantation genetic testing for monogenic disorders (PGT\u2010M) is a valuable reproductive option for hemoglobinopathy carrier\u2010couples as it precludes the initiation of an affected pregnancy. PGT\u2010M is performed on embryos generated by assisted reproductive technologies and only those found to be free of the monogenic disorder are transferred to the uterus. PGT\u2010M has been applied for 30\u2009years now and \u03b2\u2010thalassemia is one of the most common indications. PGT may also be applied for human leukocyte antigen typing to identify embryos that are unaffected and also compatible with an affected sibling in need of hemopoietic stem cell transplantation. PGT\u2010M protocols have evolved from PCR amplification\u2010based, where a small number of\u00a0loci were analysed, to whole genome amplification\u2010based, the latter increasing diagnostic accuracy, enabling the development of more generic strategies and facilitating multiple diagnoses in one embryo. Currently, numerous PGT\u2010M cycles are performed for the simultaneous diagnosis of hemoglobinopathies and screening for chromosomal abnormalities in the embryo in an attempt to further improve success rates and increase deliveries of unaffected babies.<\/jats:p>","DOI":"10.1111\/ijlh.13851","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T16:39:18Z","timestamp":1650472758000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hemoglobinopathies and preimplantation diagnostics"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-8094","authenticated-orcid":false,"given":"Thalia","family":"Mamas","sequence":"first","affiliation":[{"name":"Laboratory of Medical Genetics National and Kapodistrian University of Athens  Athens 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