{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:16:03Z","timestamp":1747185363472,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007595","name":"Belarusian Republican Foundation for Fundamental Research","doi-asserted-by":"publisher","award":["20164420"],"award-info":[{"award-number":["20164420"]}],"id":[{"id":"10.13039\/100007595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Worldwide, the B\u2010cell precursor acute lymphoblastic leukaemia (BCP\u2010ALL) treatment protocols are based on risk\u2010adaptive therapy, that is on the search for biological markers for stratification by risk groups for optimal management. Depending on the treatment protocol, deletions and overexpression of non\u2010functional IKZF1 isoforms act as relapse predictors in ALL. We investigated the IKZF1 gene aberrations as the substantive marker for predicting the development of relapse or adverse events when using risk stratification from ALL\u2010MB\u20102002\/2008 protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed the bone marrow samples collected from 202 newly diagnosed patients with BCP\u2010ALL harbouring IKZF1 aberrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients of intermediate\u2010 and high\u2010risk the presence of IKZF1 aberrations contributed to the delayed clearance of blast cells on the 15th and 36th day of induction therapy, but there was not a significant effect on relapse rate. The comparative analysis demonstrated that standard\u2010risk patients with IKZF1 aberrations have a much higher 5\u2010years cumulative incidence of relapse (66.7\u00a0\u00b1\u200922.7% vs. 11.6\u00a0\u00b1\u20092.9% in the group with normal gene status, <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001) in contrast to intermediate\u2010 and high\u2010risk groups. In the competing risk model of relapse, IKZF1 aberrations determine a high risk of relapse only in standard\u2010risk patients (<jats:italic>p<\/jats:italic>\u00a0=\u20090.025), and it was not significant for patients of other risk groups (<jats:italic>p<\/jats:italic>\u00a0=\u20090.284 for intermediate, and 0.408 for high\u2010risk groups).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings support that IKZF1 aberrations are a crucial relapse predictor in standard\u2010risk patients with BCP\u2010ALL, who practically have no significant markers to assess the prognosis during the primary diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13853","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T04:20:13Z","timestamp":1651638013000},"page":"769-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Aberrant <scp>IKZF1<\/scp> gene as relapse predictor in standard\u2010risk pediatric patients with B\u2010cell precursor acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4881-7891","authenticated-orcid":false,"given":"Volha Sergeevna","family":"Vshyukova","sequence":"first","affiliation":[{"name":"Belarusian Republican Scientific and Practical Center for Pediatric Oncology Hematology and Immunology  Borovlyani Republic of Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga Vladimirovna","family":"Krasko","sequence":"additional","affiliation":[{"name":"SSI United Institute of Informatics Problems of the National Academy of Sciences of Belarus  Minsk Republic of Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darya Alexandrovna","family":"Yanchanka","sequence":"additional","affiliation":[{"name":"Belarusian Republican Scientific and Practical Center for Pediatric Oncology Hematology and Immunology  Borovlyani Republic of Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander Nikolayevich","family":"Meleshko","sequence":"additional","affiliation":[{"name":"Belarusian Republican Scientific and Practical Center for Pediatric Oncology Hematology and Immunology  Borovlyani Republic of Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.141101"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2018.02.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.073965"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"S1","article-title":"Educational updates in hematology book","volume":"2018","author":"Harrison \u0421","year":"2018","journal-title":"HemaSphere"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2869-6"},{"key":"e_1_2_7_7_1","first-page":"31","article-title":"Preliminary results of the multicenter randomised trial ALL\u2010MB (Moscow\u2010Berlin) 2002 for childhood acute lymphoblastic leukemia in Russia and Belarus","volume":"50","author":"Karachunskiy A.","year":"2008","journal-title":"Pediatric Blood Cancer"},{"issue":"7","key":"e_1_2_7_8_1","first-page":"11","article-title":"Efficiency of the ALL\u2010MB\u20102002 protocol in children with acute lymphoblastic leukemia","volume":"82","author":"Rumiantseva IV","year":"2010","journal-title":"Ter Arkh"},{"key":"e_1_2_7_9_1","first-page":"111","article-title":"Childhood acute lymphoblastic leukemia treatment: current options and unsolved problems","volume":"10","author":"Litvinov DV","year":"2015","journal-title":"Pediatr Hematol\/Oncol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"issue":"10","key":"e_1_2_7_11_1","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. 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