{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:39:49Z","timestamp":1787506789807,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe coronavirus disease 2019 (COVID\u201019) is characterized by marked hypoxaemia and lung oedema, often accompanied by disordered blood coagulation and fibrinolytic systems, endothelial damage and intravascular fibrin deposition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>We present a retrospective observational study of 104 patients admitted to hospital with COVID\u201019. Plasma samples were collected within 72\u2009h of admission. In addition to routine coagulation and haematology testing, soluble thrombomodulin (sTM), thrombin\u2010antithrombin (TAT), tissue plasminogen activator\u2010plasminogen activator inhibitor 1 complex (tPAI\u2010C) and plasmin\u2010\u03b12 antiplasmin complex (PIC) were performed by automated chemiluminescent enzyme immunoassays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Significantly higher levels of D\u2010dimer, TAT, sTM and tPAI\u2010C were observed in non\u2010survivors compared to survivors. To confirm which parameters were independent risk factors for mortality, multiple logistic regression was performed on D\u2010dimer, TAT. sTM, tPAI\u2010C and PIC data. Only increasing sTM was significantly associated with mortality, with an odds ratio of 1.065 for each 1.0\u00a0TU\/mL increment (95% CI 1.025\u20131.115).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Of the haemostatic variables measured, sTM, which can be rapidly assayed, is the best independent predictor of mortality in patients hospitalized with COVID\u201019, and this suggests that endothelial dysfunction plays an important role in disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ijlh.13855","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T08:05:10Z","timestamp":1650614710000},"page":"817-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Automated measurement of coagulation and fibrinolytic activation markers: Outcomes in coronavirus disease 2019 (\n                    <scp>COVID<\/scp>\n                    \u201019) patients"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2318-0062","authenticated-orcid":false,"given":"Chris","family":"Gardiner","sequence":"first","affiliation":[{"name":"Specialist Laboratory Medicine St James University Hospital, Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7393-2365","authenticated-orcid":false,"given":"Ian J.","family":"Mackie","sequence":"additional","affiliation":[{"name":"Haemostasis Research Unit University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"MacCallum","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health Queen Mary University of London  London UK"},{"name":"Department of Haematology Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5466-0448","authenticated-orcid":false,"given":"Sean","family":"Platton","sequence":"additional","affiliation":[{"name":"The Royal London Haemophilia Centre Barts Health NHS Trust  London UK"},{"name":"NHS East and South East London Pathology Partnership Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12400"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14768"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14888"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616068"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14975"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731711"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2021.104224"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30216-7"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15327"},{"key":"e_1_2_9_11_1","unstructured":"Human Tissue Act 2004.United Kingdom;2004.https:\/\/www.legislation.gov.uk\/ukpga\/2004\/30"},{"key":"e_1_2_9_12_1","unstructured":"Medical Research Council.MRC 0208212 Human tissue and biological samples for use in research.https:\/\/www.ukri.org\/publications\/human-tissue-and-biological-samples-for-use-in-research\/. 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