{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:32:11Z","timestamp":1758709931269,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800112","81900122","82030005","82170124","91942306"],"award-info":[{"award-number":["81800112","81900122","82030005","82170124","91942306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder characterized by a low platelet count and increased risk of bleeding. We previously reported that low\u2010dose chidamide, a histone deacetylase (HDAC) inhibitor, restores immune tolerance in patients with ITP. This study aimed to evaluate the association of a single\u2010nucleotide polymorphism (SNP) rs2530223 in the HDAC3 gene with susceptibility to ITP and its clinical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with ITP and age\u2010matched healthy participants were recruited for this case\u2013control study. Genotyping of the HDAC3 rs2530223 polymorphism was performed using MassARRAY platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with T allele of HDAC3 rs2530223 exhibited a 1.472\u2010fold increased risk of ITP susceptibility (OR 1.472; 95% CI 1.100\u20131.969; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.009), while ones with the TT genotype under the codominant and recessive models, and the TC\/TT genotypes under the dominant model all revealed increased risk of ITP susceptibility (dominant odds ratio[OR] 1.965; 95% CI: 1.046\u20133.656; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.036; codominant OR 2.264; 95% CI 1.175\u20134.360; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.015; and recessive OR 1.512; 95% CI 1.028\u20132.224; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.036, respectively). Regarding platelet counts in ITP patients, we observed that the TC\/TT genotypes exhibited a 3.932\u2010fold increased risk for platelet (PLT) &lt;30\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L (OR 3.932; 95% CI 1.426\u201310.842; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicates that HDAC3 rs2530223 may be an important genetic factor related to ITP susceptibility and platelet count in ITP patients, providing new perspectives on disease progression, new therapeutic targets, and severity prediction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13857","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T06:31:38Z","timestamp":1651213898000},"page":"875-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>HDAC3<\/scp> single\u2010nucleotide polymorphism rs2530223 is associated with increased susceptibility and severity of primary immune thrombocytopenia"],"prefix":"10.1111","volume":"44","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Hematology Qilu Hospital, Cheeloo College of Medicine, Shandong University  Jinan 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