{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:16:05Z","timestamp":1747185365286,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008900","name":"University of South Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The recovery of adaptive immune receptor (IR) recombination reads from tumour\u2010derived genomics files has advanced the understanding of the immune system's interaction with cancer. This approach has been largely limited to solid tumours, where genomics file preparation allows for the recovery of adaptive IR reads corresponding to the T\u2010cells and B\u2010cells found in the solid tumour microenvironment. In this study, we sought to determine whether IR recombination reads from liquid tumour genomics files could also be informative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recovered the adaptive IR recombination reads from acute lymphoblastic leukaemia (ALL) normal and pathological genomics files of the Therapeutically Applicable Research to Generate Effective Treatments (TARGET)\u2010ALL, phase 2 project.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the bone marrow setting, results indicated that there was little or no B\u2010cell response to ALL. However, results did show survival distinctions for B\u2010cell ALL, in cases with specific T\u2010cell complementarity determining region\u20103 chemical features, potentially reflecting specificity of the adaptive T\u2010cell response against ALL. Furthermore, we found that the B\u2010cell form of ALL, as well as what is likely TRD clonotypic, T\u2010cell ALL, could likely be diagnosed via the recovery of B\u2010cell receptor and TRD recombination reads, respectively, from pathological bone marrow exome files.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recovery of IR recombination reads from ALL exomes could aid in sub\u2010type diagnoses and prognoses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13862","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T07:09:36Z","timestamp":1652080176000},"page":"883-891","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploiting adaptive immune receptor recombination read recoveries from exome files to identify subsets of <scp>ALL<\/scp> and to establish <scp>TCR<\/scp> features that correlate with better outcomes"],"prefix":"10.1111","volume":"44","author":[{"given":"Etienne C.","family":"Gozlan","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris I.","family":"Chobrutskiy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Oregon Health and Science University Hospital  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1664-0996","authenticated-orcid":false,"given":"George","family":"Blanck","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine, University of South Florida  Tampa Florida USA"},{"name":"Department of Immunology H. 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