{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:55:10Z","timestamp":1770069310809,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019 associated coagulopathy (CAC) can either be localized or systemic hypercoagulable state with increased risk of thromboembolism. This study looked into the usefulness of Thromboelastography (TEG) and the velocity curve (V\u2010curve) derivative from TEG in diagnosing and differentiating different stages of CAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A prospective single cohort study of RT\u2010PCR confirmed COVID\u201019 patients was carried out for 2\u2009weeks. Severe COVID\u201019 patients in the adult critical care units with a TEG report were recruited for the study. Citrated kaolin TEG was performed on the day of admission before anticoagulation. TEG parameters included were R and K time, alpha angle, maximum amplitude, clotting index, lysis at 30\u2009min. The first\u2010degree velocity curve of TEG is plotted as V\u2010curve which extrapolates thrombus generation potential. Parameters analyzed were the maximum rate of thrombus generation as well as thrombus generated (TG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 43 patients with an average age of 58.34 (\u00b115.35). TEG as well as V\u2010curve of all the patients were hypercoagulable compared with age\u2010matched reference range. We had 79.06% of patients in hypercoagulable stage. The mortality rate was 32.56% and 30.23% developed thrombotic incidents. Patients who succumbed to death had prolonged PT, aPTT, MA, Ly30, with a reduced TG (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The presence of fibrinolysis was associated with thromboembolism (OR\u00a0=\u00a06.76, CI\u00a0=\u00a01.48\u201325.82). Repeat TEG was done randomly in 11 patients and revealed a persistent hypercoagulable stage with increasing fibrinolysis activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TEG is a useful tool in diagnosing and categorizing Coagulopathy associated with COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13876","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T23:03:35Z","timestamp":1653433415000},"page":"823-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Utility of Thromboelastography and velocity curve derivative in diagnosing <scp>COVID<\/scp>\u201019 associated coagulopathy"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-9307","authenticated-orcid":false,"given":"Ganesh","family":"Mohan","sequence":"first","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion 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