{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:43:25Z","timestamp":1774496605313,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to explore the relationship between red cell distribution width (RDW) and in\u2010hospital mortality in septic shock based on a large\u2010scale public database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with septic shock in MIMIC\u2010IV were enrolled. Based on RDW values, the general characteristics of different groups were compared. Different models were constructed for exploring the association of RDW and in\u2010hospital mortality. To assess the predictive value of RDW, receiver operator characteristic (ROC) curve analysis was applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3006 patients with septic shock were included and in\u2010hospital mortality was 32.27% (n\u00a0=\u00a0970). The results of the fully adjusted model demonstrated that RDW was positively associated with in\u2010hospital mortality in septic shock patients after adjusting all confounders (OR\u00a0=\u00a01.12, 95% CI:1.08\u20131.17, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). A linear relationship between RDW and in\u2010hospital mortality was found. For predicting in\u2010hospital mortality, the area under the ROC curve (AUC) of RDW was .602 and the best threshold of RDW was 17.25%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RDW was associated with in\u2010hospital mortality in septic shock. It could be a useful marker for predicting clinical outcomes in septic shock.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13925","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T06:24:22Z","timestamp":1656138262000},"page":"861-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Red cell distribution width and in\u2010hospital mortality in septic shock: A public database research"],"prefix":"10.1111","volume":"44","author":[{"given":"Qiong","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Nursing, The Affiliated Changsha Central Hospital Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Affiliated Changsha Central Hospital Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6430-7832","authenticated-orcid":false,"given":"Changluo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Affiliated Changsha Central Hospital Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7805-2191","authenticated-orcid":false,"given":"Ning","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The Affiliated Changsha Central Hospital Hengyang Medical School, University of South China  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCE.0000000000000634"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010017\u20104821\u20101"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4266\/acc.2021.00857"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010022\u201003899\u20100"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010021\u201003883\u20100"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.53668"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13526"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.14744\/semb.2019.58159"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm\u201021\u2010425"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2014.43578"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101383564"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.18071\/isz.69.0411"},{"issue":"9","key":"e_1_2_9_14_1","first-page":"556","article-title":"Could red cell distribution width be a marker of thyroid cancer?","volume":"27","author":"Aktas G","year":"2017","journal-title":"J Coll Physicians Surg Pak JCPSP"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0000000000002296"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijccm.IJCCM_208_17"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2017.10.056"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129258"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.09.019"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613\u2010021\u201000830\u20108"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2021.07.015"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010017\u20104683\u20106"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13055"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010022\u201007201\u2010z"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739\u2010020\u201002615\u20106"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2021.01.21"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.22037\/aaem.v9i1.1325"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893\u2010021\u201001094\u20106"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14730"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/2632010x221075592"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000522261"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12873\u2010022\u201000582\u2010z"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264504"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S348490"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24297"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.06.003"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.13925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ijlh.13925","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.13925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T16:24:55Z","timestamp":1692807895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.13925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/ijlh.13925"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.13925","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,24]]},"assertion":[{"value":"2022-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}