{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:36:43Z","timestamp":1782290203308,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The aim of our study was to establish reference ranges for neonatal coagulation and fibrinolysis parameters and to investigate their relationship with gestational age (GA) and birth weight (BW).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre prospective study was conducted in all healthy neonates born in our hospital during the study period, excluding those with maternal or neonatal disorders and diseases that affect haemostasis. The following parameters were measured: fibrinogen, prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT) as well as factors II, V, VII, VIII, IX, X, XI and XII, von Willebrand (vWF), protein C, free protein S, antithrombin (AT), activated protein C resistance (APCr), tissue plasminogen activator (tPA) and plasminogen activator inhibitor\u20101 (PAI\u20101).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Study population consisted of 327 neonates. Fibrinogen, AT III, proteins C and S, PAI\u20101, vWF and factors II, V, VIII, IX, XI and XII were positively correlated, while PT, aPPT, INR, APCr and tPA were negatively correlated with GA and BW. Proteins C and S, factors II, VIII, IX, XI and vWF, as well AT III and PAI\u20101 had a significant positive linear correlation with GA, while aPTT had a significant negative one. Fibrinogen, and factors V, VII and XII had a significant positive linear correlation with BW, while factor VIII, tPA, as well PT and INR had a significant negative one.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fibrinogen, AT III, proteins C and S, PAI\u20101, vWF and factors II, V, VIII, IX, XI and XII increase with GA and BW.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13932","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T08:24:34Z","timestamp":1657527874000},"page":"952-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neonatal haemostatic parameters in correlation to gestational age and birth weight"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-1614","authenticated-orcid":false,"given":"Georgios","family":"Mitsiakos","sequence":"first","affiliation":[{"name":"Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, \u201cPapageorgiou\u201d Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios N.","family":"Katsaras","sequence":"additional","affiliation":[{"name":"Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, \u201cPapageorgiou\u201d Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Pouliakis","sequence":"additional","affiliation":[{"name":"Second Department of Pathology National and Kapodistrian University of Athens, \"ATTIKON\" University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanouil","family":"Papadakis","sequence":"additional","affiliation":[{"name":"Hematology Department \u2013 Hemostasis Unit \u201cPapageorgiou\u201d Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Chatziioannidis","sequence":"additional","affiliation":[{"name":"Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, \u201cPapageorgiou\u201d Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Mitsiakou","sequence":"additional","affiliation":[{"name":"Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, \u201cPapageorgiou\u201d Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Gialamprinou","sequence":"additional","affiliation":[{"name":"Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, \u201cPapageorgiou\u201d Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthimia","family":"Papacharalampous","sequence":"additional","affiliation":[{"name":"Second Neonatal Department and Neonatal Intensive Care Unit (NICU), Aristotle University of Thessaloniki, \u201cPapageorgiou\u201d Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kioumi","sequence":"additional","affiliation":[{"name":"Hematology Department \u2013 Hemostasis Unit \u201cPapageorgiou\u201d Hospital  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"First Paediatric Department Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fani","family":"Athanassiadou","sequence":"additional","affiliation":[{"name":"Second Paediatric Department Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Sfoungaris","sequence":"additional","affiliation":[{"name":"First Department of Pediatric Surgery, Faculty of Medicine Aristotle University of Thessaloniki, \u201cG. 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