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Renal involvement is common as the kidney is particularly susceptible to the endothelial damage and microvascular occlusion. TMAs require rapid assessment, diagnosis, and commencement of appropriate treatment due to the high morbidity and mortality associated with them. Ground\u2010breaking research into the pathogenesis of TMAs over the past 20\u2009years has driven the successful development of targeted therapeutics revolutionizing patient outcomes. 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