{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:16:16Z","timestamp":1747185376969,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The B\u2010cell lymphoma\/leukaemia 11A (<jats:italic>BCL11A<\/jats:italic>) gene encodes a Kr\u00fcppel\u2010like transcription factor involved in lymphocyte development during normal haematopoiesis. Aberrant expression of <jats:italic>BCL11A<\/jats:italic> has been observed in several haematological malignancies, including chronic lymphocytic leukaemia (CLL). However, its functions in the regulatory networks of malignant B lymphocytes are poorly understood, as are the relations to clinical course and outcome of B\u2010cell malignancies, particularly CLL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression of <jats:italic>BCL11A<\/jats:italic> was analysed in peripheral blood mononuclear cells of 87 newly\u2010diagnosed CLL patients by quantitative reverse\u2010transcriptase polymerase chain reaction (qRT\u2010PCR), and association with clinical and molecular variables was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>BCL11A<\/jats:italic> was significantly overexpressed in CLL samples compared to control samples (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). <jats:italic>BCL11A<\/jats:italic> expression level exhibited no association with age, sex, leukocyte, lymphocyte and platelet counts, haemoglobin level, serum \u03b22\u2010microglobulin, CD38 status and cytogenetic abnormalities. On the other hand, high <jats:italic>BCL11A<\/jats:italic> expression was associated with low serum lactate dehydrogenase (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.031), Binet A stage (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.047) and mutated <jats:italic>IGHV<\/jats:italic> (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.028). In addition, a positive correlation with <jats:italic>BCL2\/BAX<\/jats:italic> mRNA ratio was observed (r\u00a0=\u00a00.36; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Regarding the association with the time to first treatment (TTFT), a trend towards longer median TTFT in <jats:italic>BCL11A<\/jats:italic> high\u2010 versus <jats:italic>BCL11A<\/jats:italic> low\u2010expressing cases was detected (21 vs. 6\u00a0months; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.164).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this study show that <jats:italic>BCL11A<\/jats:italic> is upregulated in CLL patients, and that high <jats:italic>BCL11A<\/jats:italic> expression at diagnosis may be associated with better prognosis. These data are consistent with the role of <jats:italic>BCL11A<\/jats:italic> expression in CLL biology, and imply its potential prognostic relevance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13969","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T09:51:53Z","timestamp":1663581113000},"page":"64-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Expression of <i>BCL11A<\/i> in chronic lymphocytic leukaemia"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-6215","authenticated-orcid":false,"given":"Natasa","family":"Tosic","sequence":"first","affiliation":[{"name":"Institute of Molecular Genetics and Genetic Engineering University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Ugrin","sequence":"additional","affiliation":[{"name":"Institute of Molecular Genetics and 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