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Whether the poor prognostic value of Ecotropic Viral Integration site\u20101 (EVI1) overexpression suits either the subtypes of KMT2A\u2010MLLT3 or Non\u2010KMT2A\u2010MLLT3 AML patients (intermediate and high risk group) needs to be further investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the clinical characteristics of 166 KMT2A\u2010r and KMT2A\u2010PTD AML patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For the Non\u2010KMT2A\u2010MLLT3 group, patients in the EVI1\u2010high subgroup had shorter OS and DFS and higher CIR than those in the EVI1\u2010low subgroup (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.027, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.018, and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.020, respectively). Additionally, both KMT2A\u2010MLLT3 and Non\u2010KMT2A\u2010MLLT3 patients who received chemotherapy alone had poorer prognosis than patients who also received allogeneic hematopoietic stem cell transplant (allo\u2010HSCT) regardless of their EVI1 expression level (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). For transplanted patients with KMT2A\u2010MLLT3 or Non\u2010KMT2A\u2010MLLT3 rearrangement, the EVI1\u2010high subgroup had worse prognosis than the EVI1\u2010low subgroup (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The 2\u2010year CIR of the KMT2A\u2010MLLT3 and Non\u2010KMT2A\u2010MLLT3 groups with high EVI1 expression was high (52% and 49.6%, respectively). However, for patients with low EVI1 expression, the 2\u2010year CIR of transplanted patients with KMT2A\u2010MLLT3 and Non\u2010KMT2A\u2010MLLT3 was relatively low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed that for the Non\u2010KMT2A\u2010MLLT3 group, the EVI1\u2010high group had shorter OS and DFS than the EVI1\u2010low group. High EVI1 expression showed an adverse effect in AML with KMT2A rearrangement in different risk stratification subtypes. For the EVI1\u2010high patients with non\u2010KMT2A\u2010MLLT3 rearrangement, other novel regimens towards relapse should be taken into consideration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.13987","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T05:19:21Z","timestamp":1668143961000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The adverse impact of ecotropic viral integration site\u20101 (<scp>EVI1<\/scp>) overexpression on the prognosis of acute myeloid leukemia with <scp>KMT2A<\/scp> gene rearrangement in different risk stratification subtypes"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-7827","authenticated-orcid":false,"given":"Xin\u2010xin","family":"Liu","sequence":"first","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"},{"name":"Beijing Hightrust Diagnostics, Co., Ltd  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010an","family":"Pan","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-5625","authenticated-orcid":false,"given":"Meng\u2010ge","family":"Gao","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing 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Institute of Hematology, National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation  Beijing 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