{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:30:04Z","timestamp":1789057804290,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The clot waveform analysis (CWA) provide valuable information beyond clotting time. The present study was planned to assess whether the activated partial thromboplastin time (aPTT)\u2010CWA can differentiate between hemophilia A (HA), hemophilia B (HB), or hemophilia A with inhibitors (HAWI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The aPTT\u2010CWA was generated by an optical detection system (ACL\u2010TOP\u2122 500 coagulation analyzer) and the other tests were performed as per instructions from the manufacturer in the kit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 75 samples (47\u2010HA, 16\u2010HAWI, and 12\u2010HB) with prolonged aPTT were recruited. On analyzing the quantitative aPTT\u2010CWA data of HA (non\u2010inhibitors) and HB samples, the width of acceleration 1 [+] peak was the differentiating finding. Among the significant parameters, the second derivative [+] peak was lower in both mild and moderate HA, equating to HB. The time for the height of 1\/2 fibrin formation and width of velocity was significantly higher in mild, moderate and severe HA. The study did not show any significant differentiating finding while comparing HAWI and hemophilia A non\u2010inhibitors (HANI). In the subgroups of HAWI and HANI with aPTT &lt;70\u2009s and 70\u2013100\u2009s, the second derivative [+] peak (2A) was higher and the time for the height of 1\/2 fibrin formation (1C) was lesser in HAWI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The aPTT\u2010CWA parameters may be supportive for the differentiation of hemophilia including its severity and the existence of inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14008","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T08:35:03Z","timestamp":1670661303000},"page":"241-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The activated partial thromboplastin time\u2010clot waveform analysis in hemophilia: Does it help in differentiation?"],"prefix":"10.1111","volume":"45","author":[{"given":"Khalid Abdul","family":"Mannan","sequence":"first","affiliation":[{"name":"Department of Hematology Postgraduate Institute of Medical Education and Research, Sector 12  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-4171","authenticated-orcid":false,"given":"Narender","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Hematology Postgraduate Institute of Medical Education and Research, Sector 12  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Ahluwalia","sequence":"additional","affiliation":[{"name":"Department of Hematology Postgraduate Institute of Medical Education and Research, Sector 12  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chander","family":"Hans","sequence":"additional","affiliation":[{"name":"Department of Hematology Postgraduate Institute of Medical Education and Research, Sector 12  Chandigarh 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