{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:40:43Z","timestamp":1757698843632,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Diffuse large B cell lymphoma (DLBCL) is the most common type of non\u2010Hodgkin lymphoma. Although it is a clinically and biologically heterogeneous disease, it is usually treated with R\u2010CHOP chemotherapy. Here, we aimed to investigate gene expression frequency with next\u2010generation sequencing (NGS) and the relation of gene mutations with remission and relapse status in patients with DLBCLs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We investigated gene mutation profiles by NGS in patients with DLBCL\u2010NOS and analyzed the correlation between gene mutations and response and relapse rates and other clinical indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010eight of forty patients were evaluated. The most commonly mutated genes were <jats:italic>ANKRD<\/jats:italic>, <jats:italic>BRCA1<\/jats:italic>, <jats:italic>BRCA2<\/jats:italic>, <jats:italic>EZH2<\/jats:italic>, <jats:italic>KMTC2<\/jats:italic>, <jats:italic>MYC<\/jats:italic>, <jats:italic>MYD88<\/jats:italic>, <jats:italic>NF1<\/jats:italic>, <jats:italic>NOTCH1<\/jats:italic>, <jats:italic>PMS2<\/jats:italic>, <jats:italic>PTEN<\/jats:italic>, and <jats:italic>WRN<\/jats:italic>. The relapse rate was found higher in DLBCL patients with <jats:italic>ANKRD26<\/jats:italic>, <jats:italic>BRCA2<\/jats:italic>, <jats:italic>MYD88<\/jats:italic>, <jats:italic>and NOTCH1<\/jats:italic> mutations. Also, remission duration was found shorter in patients with <jats:italic>ANKRD26<\/jats:italic>, <jats:italic>BRCA2<\/jats:italic>, <jats:italic>and MYD88<\/jats:italic> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrates that the presence of some genetic mutations is effective on prognosis in patients with DLBCL. NGS\u2010based evaluation of DLBCL treatment can be used in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14012","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T11:35:48Z","timestamp":1672227348000},"page":"310-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The evaluation of gene mutation profiles by next\u2010generation sequencing in diffuse large B\u2010cell lymphoma"],"prefix":"10.1111","volume":"45","author":[{"given":"Azime","family":"\u00d6z\u00e7al\u0131ml\u0131","sequence":"first","affiliation":[{"name":"Internal Medicine Department Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim Halil","family":"Erdo\u011fdu","sequence":"additional","affiliation":[{"name":"Molecular Pathology Department Adnan Menderes University  Ayd\u0131n 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