{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:48:37Z","timestamp":1775782117156,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Erythrocyte indices LHD and Maf are complementary parameters to complete blood count and have been shown as reliable iron deficiency markers in different clinical settings. The aim of the study was to assess diagnostic performances of LHD and Maf in detecting iron deficiency in nonanaemic stable COPD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 93 nonanaemic stable COPD patients were classified as either iron deficient (ID, <jats:italic>N<\/jats:italic>\u00a0=\u00a015) or non\u2010iron deficient (non\u2010ID, <jats:italic>N<\/jats:italic>\u00a0=\u00a078). Iron deficiency was defined as a ferritin level\u2009&lt;\u2009100\u2009\u03bcg\/L with a transferrin saturation (TSAT) &lt;20%. A complete blood count, including LHD and Maf as well as other relevant inflammation and iron status parameters were obtained for all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both LHD and Maf have shown significant differences between the ID and non\u2010ID group with <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007 respectively. The AUC for LHD was .744 (95% CI: .626\u2013.863, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003) with the best cut\u2010off of 5.85 and sensitivity of 80% (95% CI: 76.0\u201384.0) and specificity of 61.5% (95% CI: 58.4\u201364.6). The AUC for Maf was .707 with optimal cut\u2010off value 12.65 and sensitivity of 83.3% (95% CI: 79.1\u201387.5) and specificity of 60.0% (95% CI: 57.0\u201363.0). Furthermore, LHD performance was not affected by vitamin B12 status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LHD and Maf are useful for iron deficiency diagnosis in stable COPD patients. LHD was shown to be resistant to vitamin B12 deficiency, which is of substantial importance in specific patient subpopulations. Both parameters are not technology\u2010dependant and do not require additional sample and\/or reagent volume, which makes them cost\u2010effective and convenient for everyday use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14029","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T09:39:08Z","timestamp":1675849148000},"page":"394-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Iron deficiency in nonanaemic <scp>COPD<\/scp> patients\u2014Could <scp>Low haemoglobin density<\/scp> and <scp>Microcytic anaemia factor<\/scp> be usefull?"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-6141","authenticated-orcid":false,"given":"Marko","family":"Trtica","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Medical Biochemistry University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branislava","family":"Milenkovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade  Belgrade Serbia"},{"name":"Clinic for Pulmonology University Clinical Centre of Serbia  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Jankovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade  Belgrade Serbia"},{"name":"Clinic for Pulmonology University Clinical Centre of Serbia  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja Dimi\u0107","family":"Janji\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Belgrade  Belgrade Serbia"},{"name":"Clinic for Pulmonology University Clinical Centre of Serbia  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna Dopu\u0111a","family":"Panti\u0107","sequence":"additional","affiliation":[{"name":"Clinical Department of Pulmonology and Allergology with Immunology Zvezdara Clinical Hospital Center  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Dopsaj","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Medical Biochemistry University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rppnen.2016.12.005"},{"key":"e_1_2_7_3_1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease Global Strategy for the Diagnosis Management and prevention of chronic obstructive pulmonary disease (2018 report);2018.www.goldcopd.org"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326899"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcs024"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440\u20101681.12357"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12616"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102466\u201014\u201024"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201006\u2010856500"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2015.07.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12591"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.06.039"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2015.1038744"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12115"},{"issue":"4","key":"e_1_2_7_15_1","first-page":"1094","article-title":"Low Hb density (LHD %) in the detection of latent iron deficiency in non\u2010anemic premenopausal women","volume":"4","author":"Urrechaga E","year":"2016","journal-title":"J Hum Nutr Food Sci"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u2010553X.2012.01417.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12030"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u2010553X.2011.01355.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751\u2010553X.2008.01127.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2298\/VSP180220094M"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156511"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S149805"},{"key":"e_1_2_7_23_1","unstructured":"WHO.Haemoglobin Concertration of The Diagnosis of Anemia and Assessment of Severity. 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