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First introduced into clinical practice in 2017, CAR T\u2010cell therapy is now finding its place in the management of lymphoid malignancies, primarily of B\u2010cell lineage, including lymphoblastic leukaemia, non\u2010Hodgkin lymphoma and plasma cell myeloma, with remarkable therapeutic outcomes. CAR T\u2010cells are a customised therapeutic product for each patient. Manufacture commences with collection of autologous T\u2010cells, which are then genetically engineered ex vivo to express transmembrane CARs. These chimeric proteins consist of an antibody\u2010like extracellular antigen\u2010binding domain, to recognise specific antigens on the surface of tumour cells (e.g. CD19), linked to the intracellular co\u2010stimulatory signalling domains of a T\u2010cell receptor (e.g. CD137). The latter is required for in vivo CAR T\u2010cell proliferation, survival, and durable efficacy. Following reinfusion, CAR T\u2010cells harness the cytotoxic capacity of a patient's immune system. 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