{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:08:34Z","timestamp":1789880914898,"version":"4.0.1"},"reference-count":105,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>United States Food and Drug Administration (FDA)\u2010approved viscoelastic testing (VET) methodologies have significantly changed in the last 10\u2009years, with the availability of cartridge\u2010based VET. Some of these cartridge\u2010based methodologies use harmonic resonance\u2010based clot detection. While VET has always allowed for the evaluation of real\u2010time clot formation, cartridge\u2010based VET provides increased ease of use as well as greater portability and robustness of results in out\u2010of\u2010laboratory environments. Here we review the use of VET in a variety of clinical contexts, including cardiac surgery, trauma, liver transplant, obstetrics, and hypercoagulable states such as COVID\u201019. As of now, high quality randomized trial evidence for new generation VET (TEG 6s, HemoSonics Quantra, ROTEM sigma) is limited. Nevertheless, the use of VET\u2010guided transfusion algorithms appears to result in reduced blood usage without worsening of patient outcomes. Future work comparing the new generation VET instruments and continuing to validate clinically important cut\u2010offs will help move the field of point\u2010of\u2010care coagulation monitoring forward and increase the quality of transfusion management in bleeding patients.<\/jats:p>","DOI":"10.1111\/ijlh.14144","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T02:33:49Z","timestamp":1691634829000},"page":"643-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Viscoelastic testing: Critical appraisal of new methodologies and current literature"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-2905","authenticated-orcid":false,"given":"Geoffrey D.","family":"Wool","sequence":"first","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Carll","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","first-page":"S1","article-title":"Basic principles of viscoelastic testing","volume":"60","author":"Carll T","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2018.08.203"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta19580"},{"key":"e_1_2_9_5_1","volume-title":"Detecting, managing and monitoring haemostasis: viscoelastometric point\u2010of\u2010care testing (ROTEM, TEG, and Sonoclot systems)","year":"2014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2020.01.033"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000463"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.04.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14265"},{"key":"e_1_2_9_10_1","volume-title":"Advanced Trauma Life Support","author":"ACS","year":"2017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15524"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2347-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.03.036"},{"issue":"8","key":"e_1_2_9_14_1","article-title":"Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding","volume":"2018","author":"Wikkelso A","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"e_1_2_9_15_1","first-page":"S101","article-title":"Viscoelastic testing in benign hematologic disorders: clinical perspectives and future implications of point\u2010of\u2010care testing to assess hemostatic competence","volume":"60","author":"Speybroeck J","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2012.11.016"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101788\u20105025"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002545"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqab028"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14542"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001032"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000859"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1581920"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004659"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001507"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001509"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001362"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.11.058"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.11.008"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/tsaco-2020-000581"},{"issue":"6","key":"e_1_2_9_31_1","first-page":"S10","article-title":"Assessment of platelet function utilizing viscoelastic testing","volume":"60","author":"Racine\u2010Brzostek SE","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9592"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.226332"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.01.011"},{"issue":"3","key":"e_1_2_9_35_1","first-page":"235","article-title":"The use of viscoelastic haemostatic assays in non\u2010cardiac surgical settings: a systematic review and meta\u2010analysis","volume":"16","author":"Franchini M","year":"2018","journal-title":"Blood Transfus"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq258"},{"issue":"6","key":"e_1_2_9_37_1","first-page":"S75","article-title":"Viscoelastic testing in pediatric patients","volume":"60","author":"Haas T","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002825"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13225"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001084"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.05.144"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2017.10.003"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14628"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2021.103192"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004522"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2015.01.028"},{"issue":"6","key":"e_1_2_9_47_1","first-page":"S52","article-title":"Viscoelastic testing in cardiac surgery","volume":"60","author":"Agarwal S","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.04.141"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex100"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000090"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-018-1217-9"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu339"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-017-0378-9"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13765"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.06.030"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023956"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200301000-00011"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2017.1325000"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006231"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14942"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X211067807"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-021-01469-5"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030860"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10052"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10020320"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005709"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2022.2119599"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.04.066"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000109"},{"key":"e_1_2_9_70_1","volume-title":"Thromboelastography or Rotational Thromboelastography for Trauma: A Review of the Clinical and Cost\u2010Effectiveness and Guidelines","author":"MacDonald E","year":"2017"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001608"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06266-1"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004234"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001699"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12078"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.01.006"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001160"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/as9.0000000000000116"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.243"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-021-07376-6"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15398"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000001780"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew023"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.09.046"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14461"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14882"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2016-0009"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2018.08.008"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex181"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.10.031"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.14722.1"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30638-4"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0549-2"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOT.0000000000001714"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2017.03.001"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10081740"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1725-9221"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10143097"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12798"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-021-02438-y"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15016"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1400-6034"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2020.05.007"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1756303"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.07.009"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25319"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.14144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:58:39Z","timestamp":1694397519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.14144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":105,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/ijlh.14144"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.14144","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,9]]},"assertion":[{"value":"2023-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}