{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:34:55Z","timestamp":1781922895581,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Detection of iron deficiency (ID) remains challenging. We aimed to evaluate the performance of reticulocyte hemoglobin equivalent (Ret\u2010He) as a potential diagnostic marker to assess ID and iron deficiency anemia (IDA) in a large pediatric cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 3158 patients (aged 15\u2009days to 19\u2009years with a median age of 8.5\u2009years; 60.2% female) were retrospectively studied. Statistical analysis was performed (a) to evaluate relationship of Ret\u2010He with other relevant complete blood count and iron panel parameters; (b) to compare the levels of Ret\u2010He in ID and IDA groups to a control group; and (c) to assess sensitivity and specificity of Ret\u2010He in ID, IDA, and anemia without ID groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ret\u2010He values were significantly positively correlated to ferritin and transferrin saturation (TSAT). The median Ret\u2010He was significantly lower in ID. A Ret\u2010He cutoff of \u226430.0\u2009pg distinguished cases of ID from the control group with a sensitivity of 90.2%, specificity of 59.5%, and area under curve (AUC) of 0.88. Ret\u2010He showed better diagnostic performance in the IDA group and acceptable performance for ID without anemia. The sensitivity, specificity, and AUC were 90.1%, 80.9%, and 0.93 for IDA at cutoff value of \u226427.4\u2009pg, and 80.8%, 51.1%, and 0.70 for ID without anemia at cutoff value of \u226430.8\u2009pg, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our large pediatric tertiary care hospital study demonstrates that Ret\u2010He is a reliable marker to help confirm IDA in pediatric population. However, further studies are needed for its use to capture the early stages of ID.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14188","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T08:53:49Z","timestamp":1697619229000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reticulocyte hemoglobin equivalent as a marker to assess iron deficiency: A large pediatric tertiary care hospital study"],"prefix":"10.1111","volume":"46","author":[{"given":"Izmarie","family":"Poventud\u2010Fuentes","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Pathology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Pathology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dowlin","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Pathology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridevi","family":"Devaraj","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Pathology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-6991","authenticated-orcid":false,"given":"Choladda V.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Immunology Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Pathology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO.WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations.https:\/\/apps.who.int\/iris\/rest\/bitstreams\/1272494\/retrieve. Published 2020. Accessed October 18 2021."},{"key":"e_1_2_10_3_1","unstructured":"CDC.Recommendations to Prevent and Control Iron Deficiency in the United States.https:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/00051880.htm. Published 1998. Accessed October 18 2021."},{"issue":"2","key":"e_1_2_10_4_1","first-page":"98","article-title":"Iron deficiency anemia: evaluation and management","volume":"87","author":"Short MW","year":"2013","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-56738-1.00003-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60865-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2576"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13391"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21090"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.2006.00812.x"},{"key":"e_1_2_10_11_1","unstructured":"FDA.Ret\u2010He parameter on the Sysmex model XE\u20102100 automated hematology analyzer.https:\/\/www.accessdata.fda.gov\/cdrh_docs\/reviews\/K050589.pdf. Published 2005. 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