{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:16:52Z","timestamp":1747185412303,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006191","name":"Eski\u015fehir Osmangazi \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Iron deficiency anemia (IDA) is the most common type of anemia in childhood and it leads to a hypercoagulable state. We investigated endogenous thrombin production in platelet\u2010poor plasma before and after oral iron replacement in children with IDA using the thrombin generation assay (TGA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 72 children diagnosed with IDA (IDA group) and 60 healthy children (control group) were included in the study. Blood samples were collected from the patients before and 1\u2009month after oral iron replacement. TGA parameters [lag time, time to peak, peak height, endogenous thrombin potential (ETP)] were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the IDA group, the lag time and time to peak decreased by 8.3% and 10.6%, respectively, and the endogenous thrombin potential (ETP) and peak height both increased by 30% compared to those of the control group. Compared to the values before iron replacement, 1\u2009month after iron replacement, the lag time and time to peak increased by 8.7% and 5%, respectively, and the ETP and peak height decreased by 31% and 31.3%, respectively, and became similar to those of the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children with IDA have increased endogenous thrombin production in platelet\u2010poor plasma and a tendency for hypercoagulability. These changes are reversible, and the ETP values become similar to those of healthy children 1\u2009month after iron replacement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14206","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T16:54:10Z","timestamp":1701536050000},"page":"345-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thrombin generation assay in platelet\u2010poor plasma in children with iron deficiency anemia"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8844-9309","authenticated-orcid":false,"given":"Umur","family":"\u00d6zd\u00f6l","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Eski\u015fehir Osmangazi University  Eski\u015fehir Turk\u0131ye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9172-9627","authenticated-orcid":false,"given":"Zeynep Canan","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Faculty of Medicine, Eski\u015fehir Osmangazi University  Eski\u015fehir Turk\u0131ye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6379-8326","authenticated-orcid":false,"given":"Ersin","family":"T\u00f6ret","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Faculty of Medicine, Eski\u015fehir Osmangazi University  Eski\u015fehir Turk\u0131ye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-3732","authenticated-orcid":false,"given":"H\u00fclya","family":"\u00d6zen","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Gulhane Faculty of Medicine University of Health Sciences  Ankara Turk\u0131ye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1662-3259","authenticated-orcid":false,"given":"\u00d6zcan","family":"B\u00f6r","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Faculty of Medicine, Eski\u015fehir Osmangazi University  Eski\u015fehir Turk\u0131ye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2333794X221110860"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082952"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442\u2010200x.2001.01329.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010007\u20100416\u20101"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000001060"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010020\u201001609\u20104"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2021.06.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1642439"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959\u2010022\u201000388\u2010w"},{"volume-title":"Iron Deficiency Anaemia: Assessment, Prevention, and Control. 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