{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:24:55Z","timestamp":1773206695276,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This research is aimed to evaluate the correlation between Th9\u2010associated cytokine levels in MM patients, clinical features, and therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral blood samples were taken in 52\u2009MM patients and 20 healthy volunteers matched by sex and age. The patients with MM were separated into two groups: the untreated group (27) and the remission group (25). An enzyme\u2010linked immunosorbent assay (ELISA) was used to measure the IL\u20109 plasma levels. The levels of Th9\u2010associated cytokines' mRNA expression (IL\u20109, PU.1, and IRF4) were measured in RT\u2010qPCR. We also analyzed the correlations between the IL\u20109 plasma levels and the clinical parameters of newly diagnosed MM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The IL\u20109 plasma levels and the Th9\u2010associated cytokines (IL\u20109, PU.1, and IRF4) mRNA levels in newly diagnosed MM patients were significantly elevated than those in healthy volunteers and significantly decreased after achieving remission. Moreover, PU.1 and IRF4 had a positive correlation with the IL\u20109 mRNA expression. Then, we found that the upregulation of IL\u20109 plasma levels correlates with the severity of anemia and decreased albumin Levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results demonstrate that Th9\/IL\u20109 may be involved in the pathogenesis of MM and is correlated with worse patient conditions such as lower hemoglobin and serum albumin. More work is necessary to confirm whether they might serve as a useful therapeutic target and prognostic marker for MM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14210","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T23:50:50Z","timestamp":1701993050000},"page":"322-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Th9\/<scp>IL<\/scp>\u20109 may participate in the pathogenesis of multiple myeloma"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1183-8139","authenticated-orcid":false,"given":"Yihan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology, Shanghai Fifth People's Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghua","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shanghai Fifth People's Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shanghai Fifth People's Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Huashan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shanghai Fifth People's Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shanghai Fifth People's Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Shanghai Fifth People's Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00135\u20105"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01513"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.138"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2018.09.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155271"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073587"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11072"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u201094\u2010017\u20109487\u20109_7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.908302"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102013\u2010305947"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1258"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3922"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201014\u20102748"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201015\u20101784"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403123"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010016\u20100374\u20103"},{"issue":"2","key":"e_1_2_11_18_1","first-page":"716","article-title":"Role of high expression of IL\u20109 in prognosis of CLL","volume":"7","author":"Chen N","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201005\u20101426"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1761"},{"issue":"14","key":"e_1_2_11_21_1","first-page":"3971","article-title":"STAT5 activation is required for interleukin\u20109\u2010dependent growth and transformation of lymphoid cells","volume":"60","author":"Demoulin JB","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102840"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666140414100831"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)70442\u20105"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(16)30206\u20106"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830200632"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11681"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30121"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12368"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/08977190410001720879"},{"issue":"4","key":"e_1_2_11_32_1","first-page":"513","article-title":"Serum Interleukin\u20109 concentration is associated with the hemoglobin level and renal function in patients with multiple myeloma","volume":"49","author":"Chang Y","year":"2019","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.5.1300.bloodjournal8551300"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201496"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1867"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.07.014"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjac097"},{"issue":"4","key":"e_1_2_11_38_1","first-page":"233","article-title":"Anemia in multiple myeloma","volume":"2","author":"Ludwig H","year":"2004","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(197509)36:3<842::aid\u2010cncr2820360303>3.0.co;2\u2010u"}],"container-title":["International Journal of Laboratory Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijlh.14210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T12:08:17Z","timestamp":1710850097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.14210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,6]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/ijlh.14210"],"URL":"https:\/\/doi.org\/10.1111\/ijlh.14210","archive":["Portico"],"relation":{},"ISSN":["1751-5521","1751-553X"],"issn-type":[{"value":"1751-5521","type":"print"},{"value":"1751-553X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,6]]},"assertion":[{"value":"2023-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}