{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:15:50Z","timestamp":1791778550619,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The MC\u201080 (Mindray, Shenzhen, China), a newly available artificial intelligence (AI)\u2010based digital morphology analyzer, is the focus of this study. We aim to compare the leukocyte differential performance of the Mindray MC\u201080 with that of the Sysmex DI\u201060 and the gold standard, manual microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 100 abnormal peripheral blood (PB) smears were compared across the MC\u201080, DI\u201060, and manual microscopy. Sensitivity, specificity, predictive value, and efficiency were calculated according to the Clinical and Laboratory Standards Institute (CLSI) EP12\u2010A2 guidelines. Comparisons were made using Bland\u2013Altman analysis and Passing\u2010Bablok regression analysis. Additionally, within\u2010run imprecision was evaluated using five samples, each with varying percentages of mature leukocytes and blasts, in accordance with CLSI EP05\u2010A3 guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The within\u2010run coefficient of variation (%CV) of the MC\u201080 for most cell classes in the five samples was lower than that of the DI\u201060. Sensitivities for the MC\u201080 ranged from 98.2% for nucleated red blood cells (NRBC) to 28.6% for reactive lymphocytes. The DI\u201060's sensitivities varied between 100% for basophils and reactive lymphocytes, and 11.1% for metamyelocytes. Both analyzers demonstrated high specificity, negative predictive value, and efficiency, with over 90% for most cell classes. However, the DI\u201060 showed relatively lower specificity for lymphocytes (73.2%) and lower efficiency for blasts and lymphocytes (80.1% and 78.6%, respectively) compared with the MC\u201080. Bland\u2013Altman analysis indicated that the absolute mean differences (%) ranged from 0.01 to 4.57 in MC\u201080 versus manual differential and 0.01 to 3.39 in DI\u201060 versus manual differential. After verification by technicians, both analyzers exhibited a very high correlation (<jats:italic>r<\/jats:italic>\u2009=\u20090.90\u20131.00) with the manual differential results in neutrophils, lymphocytes, and blasts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Mindray MC\u201080 demonstrated good performance for leukocyte differential in PB smears, notably exhibiting higher sensitivity for blasts identification than the DI\u201060.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14227","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T04:13:27Z","timestamp":1705032807000},"page":"457-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Performance comparison of two automated digital morphology analyzers for leukocyte differential in patients with malignant hematological diseases: Mindray <scp>MC<\/scp>\u201080 and Sysmex <scp>DI<\/scp>\u201060"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5988-8304","authenticated-orcid":false,"given":"Xianfei","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou People's Republic of China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Hangzhou Dian Medical Laboratory Center Co., Ltd  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Hangzhou Children's Hospital  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixiang","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoni","family":"Ning","sequence":"additional","affiliation":[{"name":"Hangzhou Dian Medical Laboratory Center Co., Ltd  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjun","family":"Feng","sequence":"additional","affiliation":[{"name":"Hangzhou Dian Medical Laboratory Center Co., Ltd  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-6536","authenticated-orcid":false,"given":"Dagan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2014.10.005"},{"key":"e_1_2_9_3_1","volume-title":"Reference Leukocytes (WBC) Differential Count (Proportional) and Evaluation of Instrumental Methods: Approval 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