{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:55:53Z","timestamp":1789016153723,"version":"build-2803163510"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>A previously published web\u2010based App using Gradient\u2010boosted models (GBMs) of eight laboratory parameters was established by Oster et al. to facilitate diagnosis or exclusion of myelodysplastic syndromes (MDS) in patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>To validate their algorithm, we compared 175 anemic patients with MDS diagnosis from our German MDS Registry with 1378 non\u2010MDS anemic patients who consulted various specialties in the D\u00fcsseldorf university hospital.<\/jats:p><\/jats:sec>Results<\/jats:title>Based on hemoglobin level, leukocyte and platelet count, mean corpuscular volume, absolute neutrophil count, absolute monocyte count, glucose and creatinine, plus the patients' gender and age, we could not reproduce a high negative predictive value (NPV), but confirmed a useful specificity of 90.9% and a positive predictive value (PPV) of 77.1%. 1192 of 1378 controls were correctly categorized as \u201cprobably not MDS (pnMDS)\u201d patients. A total of 65 patients were wrongly classified as \u201cprobable MDS (pMDS),\u201d of whom 48 had alternative explanations for their altered laboratory results. In a second analysis, we included 29 patients with chronic myelomonocytic leukemia (CMML) resulting in only one label as possible MDS, suggesting that highly proliferative bone marrow disorders are correctly excluded.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The possibility of reliably excluding MDS from differential diagnosis based on peripheral blood lab work appears to be attractive for patients and physicians alike while the confirmation of MDS diagnosis still requires a bone marrow biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14234","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T10:23:46Z","timestamp":1706523826000},"page":"510-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Validation of a novel algorithm with a high specificity in ruling out MDS<\/scp>"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2942-2472","authenticated-orcid":false,"given":"Felicitas","family":"Schulz","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology University Hospital of D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Nachtkamp","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology University Hospital of D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard S.","family":"Oster","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Department of Internal Medicine A Tel\u2010Aviv Sourasky Medical Center Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Mittelman","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University Tel\u2010Aviv Israel"},{"name":"Department of Hematology Tel\u2010Aviv Sourasky Medical Center Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Gattermann","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology University Hospital of D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Schweier","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Universit\u00e4tsklinik D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Barthuber","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Universit\u00e4tsklinik D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Germing","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Clinical Immunology University Hospital of D\u00fcsseldorf D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"52","article-title":"Primary myelodysplastic syndromes: analysis of prognostic factors in 235 patients and proposals for an improved scoring system","volume":"6","author":"Aul C","year":"1992","journal-title":"Leukemia"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.06.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020004055"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.02.014"},{"key":"e_1_2_10_6_1","unstructured":"WHO.Hemoglobin Concentrations for the Diagnosis of Anemia and Assessment of Severity. 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