{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:50:38Z","timestamp":1785865838241,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Lab Hematology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Diffuse large B\u2010cell lymphoma (DLBCL) is the most common subtype of non\u2010Hodgkin lymphomas. The aim of this study is to determine the relationship between the increase in the degree of fibrosis in the bone marrow and prognosis and mortality in newly diagnosed DLBCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bone marrow biopsy of 153 newly diagnosed DLBCL patients was determined by staining with reticulin, Masson's trichrome histochemical stain, and the degree of fibrosis was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the bone marrow biopsy performed at the time of diagnosis, bone marrow fibrosis (BMF) was observed in 70 patients. While BMF\u20101 was detected in 42 patients (60%), BMF\u20102 was detected in 25 patients (35%) and BMF\u20103 was detected in 3 patients (4%). As the degree of BMF increased, the median overall survival and median progression\u2010free survival times were significantly shorter (<jats:italic>p<\/jats:italic>: 0.008), (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In patients with an increased degree of BMF, a significant decrease in leukocyte and neutrophil counts was observed after chemotherapy (<jats:italic>p<\/jats:italic>: 0.004).<\/jats:p><jats:p>According to the results of the multivariate Cox regression model, it was determined that high NCCN\u2010IPI risk (HR: 8.25; %95 CI: 1.09\u201362.52; <jats:italic>p<\/jats:italic>\u2009=\u20090.041) and being BMF\u2009\u2265\u20092 (HR: 3.75; %95 CI: 1.65\u20138.51; <jats:italic>p<\/jats:italic>\u2009=\u20090.002), increased the risk of death (<jats:italic>p<\/jats:italic>\u2009=\u20090.002, \u22122 loglikelihood\u2009=\u2009392,553).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When the literature was reviewed, it was seen that this study was the first to define that bone marrow fibrosis grade 2 and above in DLBCL is a prognostic marker associated with worse survival. In the bone marrow pathology, which is examined to detect advanced disease in DLBCL, besides lymphomatous involvement, the detection of fibrosis grade is very important.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijlh.14249","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T05:48:00Z","timestamp":1708062480000},"page":"523-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic significance of bone marrow fibrosis in diffuse large B\u2010cell lymphoma"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-235X","authenticated-orcid":false,"given":"Tugba","family":"Cetintepe","sequence":"first","affiliation":[{"name":"Department of Hematology Izmir Katip Celebi University, Ataturk Training and Research Hospital  Izmir 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